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TRPC6 mediates high glucose-induced mitochondrial fission through activation of CDK5 in cultured human podocytes

Mitochondrial abnormalities contribute to the development of diabetic nephropathy (DN). However, the precise mechanisms of mitochondrial dysfunction in DN remain unclear. Transient receptor potential canonical channel-6 (TRPC6), a non-selective cation channel permeable to Ca(2+), has been shown to r...

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Detalles Bibliográficos
Autores principales:	Yu, Haomiao, Chen, Yili, Ma, Huimin, Wang, Zihan, Zhang, Rui, Jiao, Jundong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535336/ https://www.ncbi.nlm.nih.gov/pubmed/36213244 http://dx.doi.org/10.3389/fphys.2022.984760

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