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Functional Constipation is Associated with a Decline in Word Recognition 2 Years Later in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study

BACKGROUND: Consumption and cognitive impairment are the most common health problems among older adults. This study aimed to determine the effects of functional constipation on cognitive decline in community-dwelling older adults. METHODS: This was a 2-year longitudinal analysis of Korean Frailty an...

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Autores principales: Jang, Hoseok, Kim, Sunyoung, Kim, Byungsung, Kim, Miji, Jung, Jaehoon, Won, Chang Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Geriatrics Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535371/
https://www.ncbi.nlm.nih.gov/pubmed/36200290
http://dx.doi.org/10.4235/agmr.22.0092
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author Jang, Hoseok
Kim, Sunyoung
Kim, Byungsung
Kim, Miji
Jung, Jaehoon
Won, Chang Won
author_facet Jang, Hoseok
Kim, Sunyoung
Kim, Byungsung
Kim, Miji
Jung, Jaehoon
Won, Chang Won
author_sort Jang, Hoseok
collection PubMed
description BACKGROUND: Consumption and cognitive impairment are the most common health problems among older adults. This study aimed to determine the effects of functional constipation on cognitive decline in community-dwelling older adults. METHODS: This was a 2-year longitudinal analysis of Korean Frailty and Aging Cohort Study data, including 851 community-dwelling residents who participated in both the baseline and follow-up surveys. A neuropsychological test, the Consortium to Establish a Registry for Alzheimer's Disease Assessment Battery (CERAD-K), and the Korean version of the Frontal Assessment Battery (FAB) were used to evaluate cognitive function. Functional constipation was defined according to the ROME IV criteria. An analysis of covariance was used to identify the association between functional constipation and cognitive decline. RESULTS: Among the 851 participants, 8.9% had functional constipation. The patients in the constipation group were more likely to have low physical activity (15.8% vs. 8.8%), polypharmacy (61.8% vs. 45.5%), and depression (30.3% vs. 17.4%) than the non-constipation group. After adjusting for potential confounding factors, including age, sex, education years, low physical activity, polypharmacy, type 2 diabetes mellitus, depression, and baseline Cognitive Function Test score, the mean changes in Word Recognition test scores from 2018 to 2020 were -0.07 and -0.54 in the non-constipation and constipation groups, respectively (p=0.007). Other cognitive function tests (Mini-Mental State Examination, word list memory, word list recall, digit span, trail-making test, and FAB) did not show any difference in decline between the two groups (p>0.05). CONCLUSIONS: Functional constipation at baseline was associated with a decline in word recognition after 2 years.
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spelling pubmed-95353712022-10-12 Functional Constipation is Associated with a Decline in Word Recognition 2 Years Later in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study Jang, Hoseok Kim, Sunyoung Kim, Byungsung Kim, Miji Jung, Jaehoon Won, Chang Won Ann Geriatr Med Res Original Article BACKGROUND: Consumption and cognitive impairment are the most common health problems among older adults. This study aimed to determine the effects of functional constipation on cognitive decline in community-dwelling older adults. METHODS: This was a 2-year longitudinal analysis of Korean Frailty and Aging Cohort Study data, including 851 community-dwelling residents who participated in both the baseline and follow-up surveys. A neuropsychological test, the Consortium to Establish a Registry for Alzheimer's Disease Assessment Battery (CERAD-K), and the Korean version of the Frontal Assessment Battery (FAB) were used to evaluate cognitive function. Functional constipation was defined according to the ROME IV criteria. An analysis of covariance was used to identify the association between functional constipation and cognitive decline. RESULTS: Among the 851 participants, 8.9% had functional constipation. The patients in the constipation group were more likely to have low physical activity (15.8% vs. 8.8%), polypharmacy (61.8% vs. 45.5%), and depression (30.3% vs. 17.4%) than the non-constipation group. After adjusting for potential confounding factors, including age, sex, education years, low physical activity, polypharmacy, type 2 diabetes mellitus, depression, and baseline Cognitive Function Test score, the mean changes in Word Recognition test scores from 2018 to 2020 were -0.07 and -0.54 in the non-constipation and constipation groups, respectively (p=0.007). Other cognitive function tests (Mini-Mental State Examination, word list memory, word list recall, digit span, trail-making test, and FAB) did not show any difference in decline between the two groups (p>0.05). CONCLUSIONS: Functional constipation at baseline was associated with a decline in word recognition after 2 years. Korean Geriatrics Society 2022-09 2022-09-27 /pmc/articles/PMC9535371/ /pubmed/36200290 http://dx.doi.org/10.4235/agmr.22.0092 Text en Copyright © 2022 Korean Geriatrics Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jang, Hoseok
Kim, Sunyoung
Kim, Byungsung
Kim, Miji
Jung, Jaehoon
Won, Chang Won
Functional Constipation is Associated with a Decline in Word Recognition 2 Years Later in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study
title Functional Constipation is Associated with a Decline in Word Recognition 2 Years Later in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study
title_full Functional Constipation is Associated with a Decline in Word Recognition 2 Years Later in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study
title_fullStr Functional Constipation is Associated with a Decline in Word Recognition 2 Years Later in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study
title_full_unstemmed Functional Constipation is Associated with a Decline in Word Recognition 2 Years Later in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study
title_short Functional Constipation is Associated with a Decline in Word Recognition 2 Years Later in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study
title_sort functional constipation is associated with a decline in word recognition 2 years later in community-dwelling older adults: the korean frailty and aging cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535371/
https://www.ncbi.nlm.nih.gov/pubmed/36200290
http://dx.doi.org/10.4235/agmr.22.0092
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