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Cardiovascular adaptations and inflammation in marathon runners

Long-distance running has become increasingly popular. Cardiovascular adaptations to exercise are relevant to the specific sports and this is also the case in long-distance running. Significant changes regarding inflammatory and endothelial markers along with indices of oxidative stress are observed...

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Autores principales: Tsarouhas, Konstantinos, Tsitsimpikou, Christina, Samaras, Antonios, Saravanis, Christos, Kolovou, Genovefa, Bacopoulou, Flora, Spandidos, Demetrios A., Kouretas, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535392/
https://www.ncbi.nlm.nih.gov/pubmed/36277142
http://dx.doi.org/10.3892/etm.2022.11635
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author Tsarouhas, Konstantinos
Tsitsimpikou, Christina
Samaras, Antonios
Saravanis, Christos
Kolovou, Genovefa
Bacopoulou, Flora
Spandidos, Demetrios A.
Kouretas, Dimitrios
author_facet Tsarouhas, Konstantinos
Tsitsimpikou, Christina
Samaras, Antonios
Saravanis, Christos
Kolovou, Genovefa
Bacopoulou, Flora
Spandidos, Demetrios A.
Kouretas, Dimitrios
author_sort Tsarouhas, Konstantinos
collection PubMed
description Long-distance running has become increasingly popular. Cardiovascular adaptations to exercise are relevant to the specific sports and this is also the case in long-distance running. Significant changes regarding inflammatory and endothelial markers along with indices of oxidative stress are observed in marathon and ultra-marathon runners. However, data linking inflammatory marker levels with cardiovascular adaptations to marathon running are limited. The aim of the present study was to describe the cardiovascular adaptations observed in a group of ultra-marathon runners and the association with a series of inflammatory and endothelial markers measured in their plasma. A total of 43 ultra-marathon runners were assessed by echocardiography and a treadmill exercise test. Blood samples were used for tumor necrosis factor-α (TNF-α), asymmetric dimethylarginine (ADMA), interleukin (IL)-6, IL-10, C-reactive protein, creatine phosphokinase (CPK) and oxidative stress indice measurements. Ultra-marathon runners who presented augmented left ventricular (LV) end diastolic diameters >55 mm had higher ADMA values (1.07±0.07 vs. 0.99±0.08 µmol/ml, P<0.01) and lower CPK values (192.5±21.3 vs. 219.1±37.3 mg/dl, P<0.05) compared with those with normal LV diameters. Runners with a moderate and severe abnormal indexed LV mass >131 g/m(2) had statistically significant higher TNF-α values compared with runners, with mildly elevated and a normal LV mass indexed (16.2±1.42 vs. 14.0+1.16 pg/ml, P<0.05). Runners with an abnormal left atrial volume index (LAVI; >29 ml/m(2)) had higher IL-6 values compared with runners with a normal LAVI (1.09+0.19 vs. 0.99±0.08 pg/ml, P<0.05). ROC curves analysis revealed that ADMA values were able to predict an abnormal LV diameter detected by echocardiography [P<0.05; area under the curve (AUC), 0.763], while TNF-α values could predict an abnormal LV mass in marathon runners (P<0.05; AUC, 0.78). On the whole, the present study demonstrates that, in ultra-marathon runners, cardiovascular adaptations to running are characterized by a specific pattern of changes in inflammatory and endothelial markers, which in turn can be used to predict the occurrence of the observed adaptations.
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spelling pubmed-95353922022-10-21 Cardiovascular adaptations and inflammation in marathon runners Tsarouhas, Konstantinos Tsitsimpikou, Christina Samaras, Antonios Saravanis, Christos Kolovou, Genovefa Bacopoulou, Flora Spandidos, Demetrios A. Kouretas, Dimitrios Exp Ther Med Articles Long-distance running has become increasingly popular. Cardiovascular adaptations to exercise are relevant to the specific sports and this is also the case in long-distance running. Significant changes regarding inflammatory and endothelial markers along with indices of oxidative stress are observed in marathon and ultra-marathon runners. However, data linking inflammatory marker levels with cardiovascular adaptations to marathon running are limited. The aim of the present study was to describe the cardiovascular adaptations observed in a group of ultra-marathon runners and the association with a series of inflammatory and endothelial markers measured in their plasma. A total of 43 ultra-marathon runners were assessed by echocardiography and a treadmill exercise test. Blood samples were used for tumor necrosis factor-α (TNF-α), asymmetric dimethylarginine (ADMA), interleukin (IL)-6, IL-10, C-reactive protein, creatine phosphokinase (CPK) and oxidative stress indice measurements. Ultra-marathon runners who presented augmented left ventricular (LV) end diastolic diameters >55 mm had higher ADMA values (1.07±0.07 vs. 0.99±0.08 µmol/ml, P<0.01) and lower CPK values (192.5±21.3 vs. 219.1±37.3 mg/dl, P<0.05) compared with those with normal LV diameters. Runners with a moderate and severe abnormal indexed LV mass >131 g/m(2) had statistically significant higher TNF-α values compared with runners, with mildly elevated and a normal LV mass indexed (16.2±1.42 vs. 14.0+1.16 pg/ml, P<0.05). Runners with an abnormal left atrial volume index (LAVI; >29 ml/m(2)) had higher IL-6 values compared with runners with a normal LAVI (1.09+0.19 vs. 0.99±0.08 pg/ml, P<0.05). ROC curves analysis revealed that ADMA values were able to predict an abnormal LV diameter detected by echocardiography [P<0.05; area under the curve (AUC), 0.763], while TNF-α values could predict an abnormal LV mass in marathon runners (P<0.05; AUC, 0.78). On the whole, the present study demonstrates that, in ultra-marathon runners, cardiovascular adaptations to running are characterized by a specific pattern of changes in inflammatory and endothelial markers, which in turn can be used to predict the occurrence of the observed adaptations. D.A. Spandidos 2022-09-29 /pmc/articles/PMC9535392/ /pubmed/36277142 http://dx.doi.org/10.3892/etm.2022.11635 Text en Copyright: © Tsarouhas et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Tsarouhas, Konstantinos
Tsitsimpikou, Christina
Samaras, Antonios
Saravanis, Christos
Kolovou, Genovefa
Bacopoulou, Flora
Spandidos, Demetrios A.
Kouretas, Dimitrios
Cardiovascular adaptations and inflammation in marathon runners
title Cardiovascular adaptations and inflammation in marathon runners
title_full Cardiovascular adaptations and inflammation in marathon runners
title_fullStr Cardiovascular adaptations and inflammation in marathon runners
title_full_unstemmed Cardiovascular adaptations and inflammation in marathon runners
title_short Cardiovascular adaptations and inflammation in marathon runners
title_sort cardiovascular adaptations and inflammation in marathon runners
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535392/
https://www.ncbi.nlm.nih.gov/pubmed/36277142
http://dx.doi.org/10.3892/etm.2022.11635
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