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T Lymphocytes in Parkinson’s Disease
T cells are key mediators of both humoral and cellular adaptive immune responses, and their role in Parkinson’s disease (PD) is being increasingly recognized. Several lines of evidence have highlighted how T cells are involved in both the central nervous system and the periphery, leading to a profou...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535550/ https://www.ncbi.nlm.nih.gov/pubmed/35253782 http://dx.doi.org/10.3233/JPD-223152 |
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author | Contaldi, Elena Magistrelli, Luca Comi, Cristoforo |
author_facet | Contaldi, Elena Magistrelli, Luca Comi, Cristoforo |
author_sort | Contaldi, Elena |
collection | PubMed |
description | T cells are key mediators of both humoral and cellular adaptive immune responses, and their role in Parkinson’s disease (PD) is being increasingly recognized. Several lines of evidence have highlighted how T cells are involved in both the central nervous system and the periphery, leading to a profound imbalance in the immune network in PD patients. This review discusses the involvement of T cells in both preclinical and clinical studies, their importance as feasible biomarkers of motor and non-motor progression of the disease, and recent therapeutic strategies addressing the modulation of T cell response. |
format | Online Article Text |
id | pubmed-9535550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-95355502022-10-20 T Lymphocytes in Parkinson’s Disease Contaldi, Elena Magistrelli, Luca Comi, Cristoforo J Parkinsons Dis Review T cells are key mediators of both humoral and cellular adaptive immune responses, and their role in Parkinson’s disease (PD) is being increasingly recognized. Several lines of evidence have highlighted how T cells are involved in both the central nervous system and the periphery, leading to a profound imbalance in the immune network in PD patients. This review discusses the involvement of T cells in both preclinical and clinical studies, their importance as feasible biomarkers of motor and non-motor progression of the disease, and recent therapeutic strategies addressing the modulation of T cell response. IOS Press 2022-09-27 /pmc/articles/PMC9535550/ /pubmed/35253782 http://dx.doi.org/10.3233/JPD-223152 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Contaldi, Elena Magistrelli, Luca Comi, Cristoforo T Lymphocytes in Parkinson’s Disease |
title | T Lymphocytes in Parkinson’s Disease |
title_full | T Lymphocytes in Parkinson’s Disease |
title_fullStr | T Lymphocytes in Parkinson’s Disease |
title_full_unstemmed | T Lymphocytes in Parkinson’s Disease |
title_short | T Lymphocytes in Parkinson’s Disease |
title_sort | t lymphocytes in parkinson’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535550/ https://www.ncbi.nlm.nih.gov/pubmed/35253782 http://dx.doi.org/10.3233/JPD-223152 |
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