GBA1 and The Immune System: A Potential Role in Parkinson’s Disease?

It is clear that the immune system and inflammation have a role in Parkinson’s disease (PD), including sporadic PD and some genetic forms such as LRRK2-associated PD. One of the most important genes associated with PD is GBA1, as variants in this gene are found in 5–20% of PD patients in different p...

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Detalles Bibliográficos
Autores principales: Al-Azzawi, Zaid A.M., Arfaie, Saman, Gan-Or, Ziv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535551/
https://www.ncbi.nlm.nih.gov/pubmed/36057834
http://dx.doi.org/10.3233/JPD-223423
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author Al-Azzawi, Zaid A.M.
Arfaie, Saman
Gan-Or, Ziv
author_facet Al-Azzawi, Zaid A.M.
Arfaie, Saman
Gan-Or, Ziv
author_sort Al-Azzawi, Zaid A.M.
collection PubMed
description It is clear that the immune system and inflammation have a role in Parkinson’s disease (PD), including sporadic PD and some genetic forms such as LRRK2-associated PD. One of the most important genes associated with PD is GBA1, as variants in this gene are found in 5–20% of PD patients in different populations worldwide. Biallelic variants in GBA1 may cause Gaucher disease, a lysosomal storage disorder with involvement of the immune system, and other lines of evidence link GBA1 to the immune system and inflammation. In this review, we discuss these different pieces of evidence and whether the interplay between GBA1 and the immune system may have a role in PD.
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spelling pubmed-95355512022-10-20 GBA1 and The Immune System: A Potential Role in Parkinson’s Disease? Al-Azzawi, Zaid A.M. Arfaie, Saman Gan-Or, Ziv J Parkinsons Dis Review It is clear that the immune system and inflammation have a role in Parkinson’s disease (PD), including sporadic PD and some genetic forms such as LRRK2-associated PD. One of the most important genes associated with PD is GBA1, as variants in this gene are found in 5–20% of PD patients in different populations worldwide. Biallelic variants in GBA1 may cause Gaucher disease, a lysosomal storage disorder with involvement of the immune system, and other lines of evidence link GBA1 to the immune system and inflammation. In this review, we discuss these different pieces of evidence and whether the interplay between GBA1 and the immune system may have a role in PD. IOS Press 2022-09-27 /pmc/articles/PMC9535551/ /pubmed/36057834 http://dx.doi.org/10.3233/JPD-223423 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Al-Azzawi, Zaid A.M.
Arfaie, Saman
Gan-Or, Ziv
GBA1 and The Immune System: A Potential Role in Parkinson’s Disease?
title GBA1 and The Immune System: A Potential Role in Parkinson’s Disease?
title_full GBA1 and The Immune System: A Potential Role in Parkinson’s Disease?
title_fullStr GBA1 and The Immune System: A Potential Role in Parkinson’s Disease?
title_full_unstemmed GBA1 and The Immune System: A Potential Role in Parkinson’s Disease?
title_short GBA1 and The Immune System: A Potential Role in Parkinson’s Disease?
title_sort gba1 and the immune system: a potential role in parkinson’s disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535551/
https://www.ncbi.nlm.nih.gov/pubmed/36057834
http://dx.doi.org/10.3233/JPD-223423
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