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Quantifying Huntingtin Protein in Human Cerebrospinal Fluid Using a Novel Polyglutamine Length-Independent Assay

BACKGROUND: The use of biomarkers has become a major component of clinical trial design. In Huntington’s disease (HD), quantifying the amount of huntingtin protein (HTT) in patient cerebrospinal fluid (CSF) has served as a pharmacodynamic readout for HTT-lowering therapeutic approaches and is a pote...

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Detalles Bibliográficos
Autores principales:	Fodale, Valentina, Pintauro, Roberta, Daldin, Manuel, Spiezia, Maria Carolina, Macdonald, Douglas, Bresciani, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2022
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535588/ https://www.ncbi.nlm.nih.gov/pubmed/35938256 http://dx.doi.org/10.3233/JHD-220527

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