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Parkinsonism-Hyperpyrexia Syndrome and Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease: Two Cases and Literature Review

Parkinsonism-hyperpyrexia syndrome (PHS) and dyskinesia-hyperpyrexia syndrome (DHS) are rare but exhibit life-threatening complications in Parkinson’s disease (PD). We herein presented two cases of PD patients and performed a comprehensive and comparative literature review for these two syndromes. T...

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Autores principales: Wang, Jian-Yong, Huang, Jie-Fan, Zhu, Shi-Guo, Huang, Shi-Shi, Liu, Rong-Pei, Hu, Bei-Lei, Zhu, Jian-Hong, Zhang, Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535593/
https://www.ncbi.nlm.nih.gov/pubmed/35811538
http://dx.doi.org/10.3233/JPD-223362
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author Wang, Jian-Yong
Huang, Jie-Fan
Zhu, Shi-Guo
Huang, Shi-Shi
Liu, Rong-Pei
Hu, Bei-Lei
Zhu, Jian-Hong
Zhang, Xiong
author_facet Wang, Jian-Yong
Huang, Jie-Fan
Zhu, Shi-Guo
Huang, Shi-Shi
Liu, Rong-Pei
Hu, Bei-Lei
Zhu, Jian-Hong
Zhang, Xiong
author_sort Wang, Jian-Yong
collection PubMed
description Parkinsonism-hyperpyrexia syndrome (PHS) and dyskinesia-hyperpyrexia syndrome (DHS) are rare but exhibit life-threatening complications in Parkinson’s disease (PD). We herein presented two cases of PD patients and performed a comprehensive and comparative literature review for these two syndromes. The first case was diagnosed as PHS with cerebral salt wasting syndrome caused by abrupt withdrawal of antiparkinsonian medication. Her symptoms were gradually remitted with reinstitution of the medication. The second one was an early-stage PD patient diagnosed as DHS in association with abuse of antiparkinsonian drugs. Her symptoms were gradually remitted with reduced dosage of dopaminergic drugs. Results of literature reviews revealed a total of 56 and 13 cases of PHS and DHS, respectively, and they were more likely to occur in elderly and long-term PD patients. These two syndromes showed different female-to-male ratio, similar mortality, and different recovery time. There were stark differences between PHS and DHS, including triggers (abrupt drug stoppage versus drug abuse), symptoms (worsened tremor and rigidity versus continuous dyskinesia), and treatment (drug reinstitution versus drug reduction). In summary, our reports and the review provide new insights into PHS and DHS in association with PD and may facilitate rapid discrimination of the syndromes for timely and proper treatment to reduce mortality.
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spelling pubmed-95355932022-10-20 Parkinsonism-Hyperpyrexia Syndrome and Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease: Two Cases and Literature Review Wang, Jian-Yong Huang, Jie-Fan Zhu, Shi-Guo Huang, Shi-Shi Liu, Rong-Pei Hu, Bei-Lei Zhu, Jian-Hong Zhang, Xiong J Parkinsons Dis Review Parkinsonism-hyperpyrexia syndrome (PHS) and dyskinesia-hyperpyrexia syndrome (DHS) are rare but exhibit life-threatening complications in Parkinson’s disease (PD). We herein presented two cases of PD patients and performed a comprehensive and comparative literature review for these two syndromes. The first case was diagnosed as PHS with cerebral salt wasting syndrome caused by abrupt withdrawal of antiparkinsonian medication. Her symptoms were gradually remitted with reinstitution of the medication. The second one was an early-stage PD patient diagnosed as DHS in association with abuse of antiparkinsonian drugs. Her symptoms were gradually remitted with reduced dosage of dopaminergic drugs. Results of literature reviews revealed a total of 56 and 13 cases of PHS and DHS, respectively, and they were more likely to occur in elderly and long-term PD patients. These two syndromes showed different female-to-male ratio, similar mortality, and different recovery time. There were stark differences between PHS and DHS, including triggers (abrupt drug stoppage versus drug abuse), symptoms (worsened tremor and rigidity versus continuous dyskinesia), and treatment (drug reinstitution versus drug reduction). In summary, our reports and the review provide new insights into PHS and DHS in association with PD and may facilitate rapid discrimination of the syndromes for timely and proper treatment to reduce mortality. IOS Press 2022-09-02 /pmc/articles/PMC9535593/ /pubmed/35811538 http://dx.doi.org/10.3233/JPD-223362 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wang, Jian-Yong
Huang, Jie-Fan
Zhu, Shi-Guo
Huang, Shi-Shi
Liu, Rong-Pei
Hu, Bei-Lei
Zhu, Jian-Hong
Zhang, Xiong
Parkinsonism-Hyperpyrexia Syndrome and Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease: Two Cases and Literature Review
title Parkinsonism-Hyperpyrexia Syndrome and Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease: Two Cases and Literature Review
title_full Parkinsonism-Hyperpyrexia Syndrome and Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease: Two Cases and Literature Review
title_fullStr Parkinsonism-Hyperpyrexia Syndrome and Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease: Two Cases and Literature Review
title_full_unstemmed Parkinsonism-Hyperpyrexia Syndrome and Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease: Two Cases and Literature Review
title_short Parkinsonism-Hyperpyrexia Syndrome and Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease: Two Cases and Literature Review
title_sort parkinsonism-hyperpyrexia syndrome and dyskinesia-hyperpyrexia syndrome in parkinson’s disease: two cases and literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535593/
https://www.ncbi.nlm.nih.gov/pubmed/35811538
http://dx.doi.org/10.3233/JPD-223362
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