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Importance of Accounting for Regional Differences in Modifiable Risk Factors for Alzheimer’s Disease and Related Dementias: The Case for Tailored Interventions

BACKGROUND: We recently estimated that 36.9% of Alzheimer’s disease and related dementias (ADRD) cases in the US may be attributable to modifiable risk factors, but it is not known whether national estimates generalize to specific states or regions. OBJECTIVE: To compare national estimates of modifi...

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Autores principales: Hoffmann, Coles M., Nianogo, Roch A., Yaffe, Kristine, Rosenwohl-Mack, Amy, Carrasco, Anna, Barnes, Deborah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535596/
https://www.ncbi.nlm.nih.gov/pubmed/35938249
http://dx.doi.org/10.3233/JAD-220278
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author Hoffmann, Coles M.
Nianogo, Roch A.
Yaffe, Kristine
Rosenwohl-Mack, Amy
Carrasco, Anna
Barnes, Deborah E.
author_facet Hoffmann, Coles M.
Nianogo, Roch A.
Yaffe, Kristine
Rosenwohl-Mack, Amy
Carrasco, Anna
Barnes, Deborah E.
author_sort Hoffmann, Coles M.
collection PubMed
description BACKGROUND: We recently estimated that 36.9% of Alzheimer’s disease and related dementias (ADRD) cases in the US may be attributable to modifiable risk factors, but it is not known whether national estimates generalize to specific states or regions. OBJECTIVE: To compare national estimates of modifiable risk factors of ADRD to California, overall and by sex and race/ethnicity, and to estimate number of cases potentially preventable by reducing the prevalence of key risk factors by 25%. METHODS: Adults ≥18 years who participated in the Behavioral Risk Factor Surveillance Survey in California (n = 9,836) and the US (n = 378,615). We calculated population attributable risks (PARs) for eight risk factors (physical inactivity, current smoking, depression, low education, diabetes mellitus, midlife obesity, midlife hypertension, and hearing loss) and compared estimates in California and the U.S. RESULTS: In California, overall, 28.9% of ADRD cases were potentially attributable to the combination of risk factors, compared to 36.9% in the U.S. The top three risk factors were the same in California and the U.S., although their relative importance differed (low education [CA:14.9%; U.S.:11.7% ], midlife obesity [CA:14.9%; U.S.:17.7% ], and physical inactivity [CA:10.3%; U.S.:11.8% ]). The number of ADRD cases attributable to the combined risk factors was 199,246 in California and 2,287,683 in the U.S. If the combined risk factors were reduced by 25%, we could potentially prevent more than 40,000 cases in California and 445,000 cases in the U.S. CONCLUSION: Our findings highlight the importance of examining risk factors of ADRD regionally, and within sex and race/ethnic groups to tailor dementia risk reduction strategies.
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spelling pubmed-95355962022-10-20 Importance of Accounting for Regional Differences in Modifiable Risk Factors for Alzheimer’s Disease and Related Dementias: The Case for Tailored Interventions Hoffmann, Coles M. Nianogo, Roch A. Yaffe, Kristine Rosenwohl-Mack, Amy Carrasco, Anna Barnes, Deborah E. J Alzheimers Dis Research Article BACKGROUND: We recently estimated that 36.9% of Alzheimer’s disease and related dementias (ADRD) cases in the US may be attributable to modifiable risk factors, but it is not known whether national estimates generalize to specific states or regions. OBJECTIVE: To compare national estimates of modifiable risk factors of ADRD to California, overall and by sex and race/ethnicity, and to estimate number of cases potentially preventable by reducing the prevalence of key risk factors by 25%. METHODS: Adults ≥18 years who participated in the Behavioral Risk Factor Surveillance Survey in California (n = 9,836) and the US (n = 378,615). We calculated population attributable risks (PARs) for eight risk factors (physical inactivity, current smoking, depression, low education, diabetes mellitus, midlife obesity, midlife hypertension, and hearing loss) and compared estimates in California and the U.S. RESULTS: In California, overall, 28.9% of ADRD cases were potentially attributable to the combination of risk factors, compared to 36.9% in the U.S. The top three risk factors were the same in California and the U.S., although their relative importance differed (low education [CA:14.9%; U.S.:11.7% ], midlife obesity [CA:14.9%; U.S.:17.7% ], and physical inactivity [CA:10.3%; U.S.:11.8% ]). The number of ADRD cases attributable to the combined risk factors was 199,246 in California and 2,287,683 in the U.S. If the combined risk factors were reduced by 25%, we could potentially prevent more than 40,000 cases in California and 445,000 cases in the U.S. CONCLUSION: Our findings highlight the importance of examining risk factors of ADRD regionally, and within sex and race/ethnic groups to tailor dementia risk reduction strategies. IOS Press 2022-09-13 /pmc/articles/PMC9535596/ /pubmed/35938249 http://dx.doi.org/10.3233/JAD-220278 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hoffmann, Coles M.
Nianogo, Roch A.
Yaffe, Kristine
Rosenwohl-Mack, Amy
Carrasco, Anna
Barnes, Deborah E.
Importance of Accounting for Regional Differences in Modifiable Risk Factors for Alzheimer’s Disease and Related Dementias: The Case for Tailored Interventions
title Importance of Accounting for Regional Differences in Modifiable Risk Factors for Alzheimer’s Disease and Related Dementias: The Case for Tailored Interventions
title_full Importance of Accounting for Regional Differences in Modifiable Risk Factors for Alzheimer’s Disease and Related Dementias: The Case for Tailored Interventions
title_fullStr Importance of Accounting for Regional Differences in Modifiable Risk Factors for Alzheimer’s Disease and Related Dementias: The Case for Tailored Interventions
title_full_unstemmed Importance of Accounting for Regional Differences in Modifiable Risk Factors for Alzheimer’s Disease and Related Dementias: The Case for Tailored Interventions
title_short Importance of Accounting for Regional Differences in Modifiable Risk Factors for Alzheimer’s Disease and Related Dementias: The Case for Tailored Interventions
title_sort importance of accounting for regional differences in modifiable risk factors for alzheimer’s disease and related dementias: the case for tailored interventions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535596/
https://www.ncbi.nlm.nih.gov/pubmed/35938249
http://dx.doi.org/10.3233/JAD-220278
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