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Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes

BACKGROUND: There are few studies on the locus coeruleus (LC) in frontotemporal lobar degeneration (FTLD) and the potential differences in the LC related to the underlying proteinopathy. OBJECTIVE: The aim of this study was to investigate the LC in FTLD subgroups. METHODS: Neuropathological cases di...

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Autores principales: Matti, Nathalie, Javanshiri, Keivan, Haglund, Mattias, Saenz-Sardá, Xavier, Englund, Elisabet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535600/
https://www.ncbi.nlm.nih.gov/pubmed/35871340
http://dx.doi.org/10.3233/JAD-220276
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author Matti, Nathalie
Javanshiri, Keivan
Haglund, Mattias
Saenz-Sardá, Xavier
Englund, Elisabet
author_facet Matti, Nathalie
Javanshiri, Keivan
Haglund, Mattias
Saenz-Sardá, Xavier
Englund, Elisabet
author_sort Matti, Nathalie
collection PubMed
description BACKGROUND: There are few studies on the locus coeruleus (LC) in frontotemporal lobar degeneration (FTLD) and the potential differences in the LC related to the underlying proteinopathy. OBJECTIVE: The aim of this study was to investigate the LC in FTLD subgroups. METHODS: Neuropathological cases diagnosed with FTLD were included. The subgroups consisted of FTLD with tau, transactive response DNA-binding protein 43 (TDP) and fused in sarcoma (FUS). Micro- and macroscopical degeneration of the LC were assessed with respect to the number of neurons and the degree of depigmentation. A group of cognitively healthy subjects and a group with vascular cognitive impairment (VCI) served as comparison groups. RESULTS: A total of 85 FTLD cases were included, of which 44 had FTLD-TDP, 38 had FTLD-tau, and three had FTLD-FUS. The groups were compared with 25 VCI cases and 41 cognitively healthy control cases (N = 151 for the entire study). All FTLD groups had a statistically higher microscopical degeneration of the LC compared to the controls, but the FTLD-tau group had greater micro- and macroscopical degeneration than the FTLD-TDP group. Age correlated positively with the LC score in the FTLD-tau group, but not in the FTLD-TDP group. CONCLUSION: A greater microscopical degeneration of the LC was observed in all FTLD cases compared to healthy controls and those with VCI. The LC degeneration was more severe in FTLD-tau than in FTLD-TDP. The macroscopically differential degeneration of the LC in FTLD subgroups may facilitate differential diagnostics, potentially with imaging.
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spelling pubmed-95356002022-10-20 Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes Matti, Nathalie Javanshiri, Keivan Haglund, Mattias Saenz-Sardá, Xavier Englund, Elisabet J Alzheimers Dis Research Article BACKGROUND: There are few studies on the locus coeruleus (LC) in frontotemporal lobar degeneration (FTLD) and the potential differences in the LC related to the underlying proteinopathy. OBJECTIVE: The aim of this study was to investigate the LC in FTLD subgroups. METHODS: Neuropathological cases diagnosed with FTLD were included. The subgroups consisted of FTLD with tau, transactive response DNA-binding protein 43 (TDP) and fused in sarcoma (FUS). Micro- and macroscopical degeneration of the LC were assessed with respect to the number of neurons and the degree of depigmentation. A group of cognitively healthy subjects and a group with vascular cognitive impairment (VCI) served as comparison groups. RESULTS: A total of 85 FTLD cases were included, of which 44 had FTLD-TDP, 38 had FTLD-tau, and three had FTLD-FUS. The groups were compared with 25 VCI cases and 41 cognitively healthy control cases (N = 151 for the entire study). All FTLD groups had a statistically higher microscopical degeneration of the LC compared to the controls, but the FTLD-tau group had greater micro- and macroscopical degeneration than the FTLD-TDP group. Age correlated positively with the LC score in the FTLD-tau group, but not in the FTLD-TDP group. CONCLUSION: A greater microscopical degeneration of the LC was observed in all FTLD cases compared to healthy controls and those with VCI. The LC degeneration was more severe in FTLD-tau than in FTLD-TDP. The macroscopically differential degeneration of the LC in FTLD subgroups may facilitate differential diagnostics, potentially with imaging. IOS Press 2022-09-13 /pmc/articles/PMC9535600/ /pubmed/35871340 http://dx.doi.org/10.3233/JAD-220276 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Matti, Nathalie
Javanshiri, Keivan
Haglund, Mattias
Saenz-Sardá, Xavier
Englund, Elisabet
Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes
title Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes
title_full Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes
title_fullStr Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes
title_full_unstemmed Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes
title_short Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes
title_sort locus coeruleus degeneration differs between frontotemporal lobar degeneration subtypes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535600/
https://www.ncbi.nlm.nih.gov/pubmed/35871340
http://dx.doi.org/10.3233/JAD-220276
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