Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei

[Image: see text] Chlorfortunones A (1) and B (2), two novel sesquiterpenoid dimers, were isolated from the roots of Chloranthus fortunei. Their structures were elucidated by spectroscopic analysis and X-ray diffraction analysis. Compounds 1 and 2 represent a new type of sesquiterpenoid dimer posses...

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Detalles Bibliográficos
Autores principales: Wu, Xu-Jia, Cao, Dai, Chen, Fei-Long, Shen, Rong-Sheng, Gao, Jin, Bai, Li-Ping, Zhang, Wei, Jiang, Zhi-Hong, Zhu, Guo-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535645/
https://www.ncbi.nlm.nih.gov/pubmed/36211056
http://dx.doi.org/10.1021/acsomega.2c03927
Descripción
Sumario:[Image: see text] Chlorfortunones A (1) and B (2), two novel sesquiterpenoid dimers, were isolated from the roots of Chloranthus fortunei. Their structures were elucidated by spectroscopic analysis and X-ray diffraction analysis. Compounds 1 and 2 represent a new type of sesquiterpenoid dimer possessing an unprecedented 3/5/6/6/6/5 hexacyclic system with a unique dispiro[4,2,5,2]pentadecane-6,10,14-trien moiety. A plausible biosynthetic pathway of 1 and 2 was proposed. Compound 1 showed transforming growth factor (TGF)-β inhibitory activity in MDA-MB-231 cells.

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