Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei

[Image: see text] Chlorfortunones A (1) and B (2), two novel sesquiterpenoid dimers, were isolated from the roots of Chloranthus fortunei. Their structures were elucidated by spectroscopic analysis and X-ray diffraction analysis. Compounds 1 and 2 represent a new type of sesquiterpenoid dimer posses...

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Autores principales: Wu, Xu-Jia, Cao, Dai, Chen, Fei-Long, Shen, Rong-Sheng, Gao, Jin, Bai, Li-Ping, Zhang, Wei, Jiang, Zhi-Hong, Zhu, Guo-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535645/
https://www.ncbi.nlm.nih.gov/pubmed/36211056
http://dx.doi.org/10.1021/acsomega.2c03927
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author Wu, Xu-Jia
Cao, Dai
Chen, Fei-Long
Shen, Rong-Sheng
Gao, Jin
Bai, Li-Ping
Zhang, Wei
Jiang, Zhi-Hong
Zhu, Guo-Yuan
author_facet Wu, Xu-Jia
Cao, Dai
Chen, Fei-Long
Shen, Rong-Sheng
Gao, Jin
Bai, Li-Ping
Zhang, Wei
Jiang, Zhi-Hong
Zhu, Guo-Yuan
author_sort Wu, Xu-Jia
collection PubMed
description [Image: see text] Chlorfortunones A (1) and B (2), two novel sesquiterpenoid dimers, were isolated from the roots of Chloranthus fortunei. Their structures were elucidated by spectroscopic analysis and X-ray diffraction analysis. Compounds 1 and 2 represent a new type of sesquiterpenoid dimer possessing an unprecedented 3/5/6/6/6/5 hexacyclic system with a unique dispiro[4,2,5,2]pentadecane-6,10,14-trien moiety. A plausible biosynthetic pathway of 1 and 2 was proposed. Compound 1 showed transforming growth factor (TGF)-β inhibitory activity in MDA-MB-231 cells.
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spelling pubmed-95356452022-10-07 Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei Wu, Xu-Jia Cao, Dai Chen, Fei-Long Shen, Rong-Sheng Gao, Jin Bai, Li-Ping Zhang, Wei Jiang, Zhi-Hong Zhu, Guo-Yuan ACS Omega [Image: see text] Chlorfortunones A (1) and B (2), two novel sesquiterpenoid dimers, were isolated from the roots of Chloranthus fortunei. Their structures were elucidated by spectroscopic analysis and X-ray diffraction analysis. Compounds 1 and 2 represent a new type of sesquiterpenoid dimer possessing an unprecedented 3/5/6/6/6/5 hexacyclic system with a unique dispiro[4,2,5,2]pentadecane-6,10,14-trien moiety. A plausible biosynthetic pathway of 1 and 2 was proposed. Compound 1 showed transforming growth factor (TGF)-β inhibitory activity in MDA-MB-231 cells. American Chemical Society 2022-09-20 /pmc/articles/PMC9535645/ /pubmed/36211056 http://dx.doi.org/10.1021/acsomega.2c03927 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Wu, Xu-Jia
Cao, Dai
Chen, Fei-Long
Shen, Rong-Sheng
Gao, Jin
Bai, Li-Ping
Zhang, Wei
Jiang, Zhi-Hong
Zhu, Guo-Yuan
Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei
title Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei
title_full Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei
title_fullStr Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei
title_full_unstemmed Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei
title_short Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei
title_sort chlorfortunones a and b, two sesquiterpenoid dimers, possessing dispiro[4,2,5,2]pentadecane-6,10,14-tren moiety from chloranthus fortunei
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535645/
https://www.ncbi.nlm.nih.gov/pubmed/36211056
http://dx.doi.org/10.1021/acsomega.2c03927
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