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Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia

Aphasia is a language disorder that occurs after a stroke and impairs listening, speaking, reading, writing, and calculation skills. Patients with post-stroke aphasia in Japan are increasing due to population aging and the advancement of medical treatment. Opportunities for adequate speech therapy i...

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Autores principales: Katsuno, Yuta, Ueki, Yoshino, Ito, Keiichi, Murakami, Satona, Aoyama, Kiminori, Oishi, Naoya, Kan, Hirohito, Matsukawa, Noriyuki, Nagao, Katashi, Tatsumi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535658/
https://www.ncbi.nlm.nih.gov/pubmed/36211132
http://dx.doi.org/10.3389/fnhum.2022.870733
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author Katsuno, Yuta
Ueki, Yoshino
Ito, Keiichi
Murakami, Satona
Aoyama, Kiminori
Oishi, Naoya
Kan, Hirohito
Matsukawa, Noriyuki
Nagao, Katashi
Tatsumi, Hiroshi
author_facet Katsuno, Yuta
Ueki, Yoshino
Ito, Keiichi
Murakami, Satona
Aoyama, Kiminori
Oishi, Naoya
Kan, Hirohito
Matsukawa, Noriyuki
Nagao, Katashi
Tatsumi, Hiroshi
author_sort Katsuno, Yuta
collection PubMed
description Aphasia is a language disorder that occurs after a stroke and impairs listening, speaking, reading, writing, and calculation skills. Patients with post-stroke aphasia in Japan are increasing due to population aging and the advancement of medical treatment. Opportunities for adequate speech therapy in chronic stroke are limited due to time constraints. Recent studies have reported that intensive speech therapy for a short period of time or continuous speech therapy using high-tech equipment, including speech applications (apps, can improve aphasia even in the chronic stage. However, its underlying mechanism for improving language function and its effect on other cognitive functions remains unclear. In the present study, we investigated whether intensive speech therapy using a newly developed speech support app could improve aphasia and other cognitive functions in patients with chronic stroke. Furthermore, we examined whether it can alter the brain network related to language and other cortical areas. Thus, we conducted a prospective, single-comparison study to examine the effects of a new speech support app on language and cognitive functions and used resting state functional MRI (rs-fMRI) regions of interest (ROI) to ROI analysis to determine changes in the related brain network. Two patients with chronic stroke participated in this study. They used the independent speech therapy system to perform eight sets of 20 randomly presented words/time (taking approximately 20 min), for 8 consecutive weeks. Their language, higher cognitive functions including attention function, and rs-fMRI, were evaluated before and after the rehabilitation intervention using the speech support app. Both patients had improved pronunciation, daily conversational situations, and attention. The rs-fMRI analysis showed increased functional connectivity of brain regions associated with language and attention related areas. Our results show that intensive speech therapy using this speech support app can improve language and attention functions even in the chronic stage of stroke, and may be a useful tool for patients with aphasia. In the future, we will conduct longitudinal studies with larger numbers of patients, which we hope will continue the trends seen in the current study, and provide even stronger evidence for the usefulness of this new speech support app.
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spelling pubmed-95356582022-10-07 Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia Katsuno, Yuta Ueki, Yoshino Ito, Keiichi Murakami, Satona Aoyama, Kiminori Oishi, Naoya Kan, Hirohito Matsukawa, Noriyuki Nagao, Katashi Tatsumi, Hiroshi Front Hum Neurosci Human Neuroscience Aphasia is a language disorder that occurs after a stroke and impairs listening, speaking, reading, writing, and calculation skills. Patients with post-stroke aphasia in Japan are increasing due to population aging and the advancement of medical treatment. Opportunities for adequate speech therapy in chronic stroke are limited due to time constraints. Recent studies have reported that intensive speech therapy for a short period of time or continuous speech therapy using high-tech equipment, including speech applications (apps, can improve aphasia even in the chronic stage. However, its underlying mechanism for improving language function and its effect on other cognitive functions remains unclear. In the present study, we investigated whether intensive speech therapy using a newly developed speech support app could improve aphasia and other cognitive functions in patients with chronic stroke. Furthermore, we examined whether it can alter the brain network related to language and other cortical areas. Thus, we conducted a prospective, single-comparison study to examine the effects of a new speech support app on language and cognitive functions and used resting state functional MRI (rs-fMRI) regions of interest (ROI) to ROI analysis to determine changes in the related brain network. Two patients with chronic stroke participated in this study. They used the independent speech therapy system to perform eight sets of 20 randomly presented words/time (taking approximately 20 min), for 8 consecutive weeks. Their language, higher cognitive functions including attention function, and rs-fMRI, were evaluated before and after the rehabilitation intervention using the speech support app. Both patients had improved pronunciation, daily conversational situations, and attention. The rs-fMRI analysis showed increased functional connectivity of brain regions associated with language and attention related areas. Our results show that intensive speech therapy using this speech support app can improve language and attention functions even in the chronic stage of stroke, and may be a useful tool for patients with aphasia. In the future, we will conduct longitudinal studies with larger numbers of patients, which we hope will continue the trends seen in the current study, and provide even stronger evidence for the usefulness of this new speech support app. Frontiers Media S.A. 2022-09-22 /pmc/articles/PMC9535658/ /pubmed/36211132 http://dx.doi.org/10.3389/fnhum.2022.870733 Text en Copyright © 2022 Katsuno, Ueki, Ito, Murakami, Aoyama, Oishi, Kan, Matsukawa, Nagao and Tatsumi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Katsuno, Yuta
Ueki, Yoshino
Ito, Keiichi
Murakami, Satona
Aoyama, Kiminori
Oishi, Naoya
Kan, Hirohito
Matsukawa, Noriyuki
Nagao, Katashi
Tatsumi, Hiroshi
Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia
title Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia
title_full Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia
title_fullStr Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia
title_full_unstemmed Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia
title_short Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia
title_sort effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with post-stroke aphasia
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535658/
https://www.ncbi.nlm.nih.gov/pubmed/36211132
http://dx.doi.org/10.3389/fnhum.2022.870733
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