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Organocatalytic Reduction of Aromatic Nitro Compounds: The Use of Solid-Supported Phenyl(2-quinolyl)methanol

[Image: see text] The reduction of aromatic nitro compounds has been performed employing a catalytic amount of Wang resin-supported phenyl(2-quinolyl)methanol (Wang-PQM) in the presence of an excess of NaBH(4) to regenerate the reactive reducing species at the end of the process. The reduction produ...

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Detalles Bibliográficos
Autores principales: Giomi, Donatella, Ceccarelli, Jacopo, Salvini, Antonella, Pinto, Marika, Brandi, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535724/
https://www.ncbi.nlm.nih.gov/pubmed/36211086
http://dx.doi.org/10.1021/acsomega.2c04196
Descripción
Sumario:[Image: see text] The reduction of aromatic nitro compounds has been performed employing a catalytic amount of Wang resin-supported phenyl(2-quinolyl)methanol (Wang-PQM) in the presence of an excess of NaBH(4) to regenerate the reactive reducing species at the end of the process. The reduction products are easily isolated through a simple filtration/extraction protocol, and the catalyst can be efficiently recovered and recycled. The condensation route is generally preferred, and azo- and/or hydrazo-arenes can be easily prepared in high yields.