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Synthesis of 7-Aminocoumarins from 7-Hydroxycoumarins via Amide Smiles Rearrangement

[Image: see text] N-Substituted 7-aminocoumarins can be synthesized from readily available 7-hydroxycoumarins via alkylation with α-bromoacetamides and subsequent tandem O → N Smiles rearrangement–amide hydrolysis. The key rearrangement sequence proceeds under mild conditions to provide convenient a...

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Detalles Bibliográficos
Autores principales:	Lippe, Daniel S., Elghawy, Omar, Zucker, Adam M., Yanagawa, Evan S. K., Mathews, Erin, Ahmed, Yusef G., D’Elia, Paige N., Bimson, Sabrina, Walvoord, Ryan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535735/ https://www.ncbi.nlm.nih.gov/pubmed/36211046 http://dx.doi.org/10.1021/acsomega.2c04653

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