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Clinical and electrocardiographic characteristics in patients with fulminant myocarditis
BACKGROUND: The purpose of this study was to evaluate clinical and electrocardiographic characteristics in patients with fulminant myocarditis. METHODS: A total of 72 patients were divided into three groups: pericarditis (control: n = 25), acute myocarditis (n = 27), and fulminant myocarditis (n = 2...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535750/ https://www.ncbi.nlm.nih.gov/pubmed/36237853 http://dx.doi.org/10.1002/joa3.12751 |
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author | Itoh, Tomonori Kobayashi, Takamasa Oshikiri, Yuya Arakawa, Yumeka Satoh, Mamoru Morino, Yoshihiro |
author_facet | Itoh, Tomonori Kobayashi, Takamasa Oshikiri, Yuya Arakawa, Yumeka Satoh, Mamoru Morino, Yoshihiro |
author_sort | Itoh, Tomonori |
collection | PubMed |
description | BACKGROUND: The purpose of this study was to evaluate clinical and electrocardiographic characteristics in patients with fulminant myocarditis. METHODS: A total of 72 patients were divided into three groups: pericarditis (control: n = 25), acute myocarditis (n = 27), and fulminant myocarditis (n = 20). Patients' characteristics and electrocardiograms on admission were retrospectively analyzed in the three groups. RESULTS: BNP levels in the fulminant group were significantly higher than those in the other two groups. ST elevation was observed at lead aVR in the fulminant myocarditis group, whereas ST depression was observed at lead aVR in the other groups (p = .001). The maximum degree of ST elevation among the three groups was similar. However, the number of ST‐elevation leads in the fulminant myocarditis group was significantly lower than that in the other groups (p = .004). The voltage of R wave in lead V5 in the fulminant myocarditis group was significantly lower than that in the other groups (p = .005). Moreover, in the Cabrera sequence, the prevalence of ST elevation in the inferior leads, aVR, and V3–V6 in the fulminant myocarditis group was significantly or nearly significantly lower than that in the other groups. CONCLUSIONS: In fulminant myocarditis, ST‐segment elevation was observed in lead aVR, and contrarily, the number and extent of ST‐segment elevation and R wave voltage were smaller than those in the other groups. These results suggest that the number of myocytes with maintained action potential may be reduced following progressive myocardial damage and interstitial edema due to severe inflammation. |
format | Online Article Text |
id | pubmed-9535750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95357502022-10-12 Clinical and electrocardiographic characteristics in patients with fulminant myocarditis Itoh, Tomonori Kobayashi, Takamasa Oshikiri, Yuya Arakawa, Yumeka Satoh, Mamoru Morino, Yoshihiro J Arrhythm Original Articles BACKGROUND: The purpose of this study was to evaluate clinical and electrocardiographic characteristics in patients with fulminant myocarditis. METHODS: A total of 72 patients were divided into three groups: pericarditis (control: n = 25), acute myocarditis (n = 27), and fulminant myocarditis (n = 20). Patients' characteristics and electrocardiograms on admission were retrospectively analyzed in the three groups. RESULTS: BNP levels in the fulminant group were significantly higher than those in the other two groups. ST elevation was observed at lead aVR in the fulminant myocarditis group, whereas ST depression was observed at lead aVR in the other groups (p = .001). The maximum degree of ST elevation among the three groups was similar. However, the number of ST‐elevation leads in the fulminant myocarditis group was significantly lower than that in the other groups (p = .004). The voltage of R wave in lead V5 in the fulminant myocarditis group was significantly lower than that in the other groups (p = .005). Moreover, in the Cabrera sequence, the prevalence of ST elevation in the inferior leads, aVR, and V3–V6 in the fulminant myocarditis group was significantly or nearly significantly lower than that in the other groups. CONCLUSIONS: In fulminant myocarditis, ST‐segment elevation was observed in lead aVR, and contrarily, the number and extent of ST‐segment elevation and R wave voltage were smaller than those in the other groups. These results suggest that the number of myocytes with maintained action potential may be reduced following progressive myocardial damage and interstitial edema due to severe inflammation. John Wiley and Sons Inc. 2022-07-08 /pmc/articles/PMC9535750/ /pubmed/36237853 http://dx.doi.org/10.1002/joa3.12751 Text en © 2022 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of Japanese Heart Rhythm Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Itoh, Tomonori Kobayashi, Takamasa Oshikiri, Yuya Arakawa, Yumeka Satoh, Mamoru Morino, Yoshihiro Clinical and electrocardiographic characteristics in patients with fulminant myocarditis |
title | Clinical and electrocardiographic characteristics in patients with fulminant myocarditis |
title_full | Clinical and electrocardiographic characteristics in patients with fulminant myocarditis |
title_fullStr | Clinical and electrocardiographic characteristics in patients with fulminant myocarditis |
title_full_unstemmed | Clinical and electrocardiographic characteristics in patients with fulminant myocarditis |
title_short | Clinical and electrocardiographic characteristics in patients with fulminant myocarditis |
title_sort | clinical and electrocardiographic characteristics in patients with fulminant myocarditis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535750/ https://www.ncbi.nlm.nih.gov/pubmed/36237853 http://dx.doi.org/10.1002/joa3.12751 |
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