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Examining evidence of time-dependent treatment effects: an illustration using regression methods
BACKGROUND: For the design and analysis of clinical trials with time-to-event outcomes, the Cox proportional hazards model and the logrank test have been the cornerstone methods for many decades. Increasingly, the key assumption of proportionality—or time-fixed effects—that underpins these methods h...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535854/ https://www.ncbi.nlm.nih.gov/pubmed/36203169 http://dx.doi.org/10.1186/s13063-022-06803-x |