Cargando…

SARS-CoV-2 Uses Nonstructural Protein 16 to Evade Restriction by IFIT1 and IFIT3

Mostrar otras versiones (1)

Understanding the molecular basis of innate immune evasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important consideration for designing the next wave of therapeutics. Here, we investigate the role of the nonstructural protein 16 (NSP16) of SARS-CoV-2 in infection and p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schindewolf, Craig, Lokugamage, Kumari, Vu, Michelle N., Johnson, Bryan A., Scharton, Dionna, Plante, Jessica A., Kalveram, Birte, Crocquet-Valdes, Patricia A., Sotcheff, Stephanea, Jaworski, Elizabeth, Alvarado, R. Elias, Debbink, Kari, Daugherty, Matthew D., Weaver, Scott C., Routh, Andrew L., Walker, David H., Plante, Kenneth S., Menachery, Vineet D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536030/ https://www.ncbi.nlm.nih.gov/pubmed/36203546 http://dx.doi.org/10.1101/2022.09.26.509529

Ejemplares similares

SARS-CoV-2 Uses Nonstructural Protein 16 To Evade Restriction by IFIT1 and IFIT3
por: Schindewolf, Craig, et al.
Publicado: (2023)

QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis
por: Vu, Michelle N., et al.
Publicado: (2022)

Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis
por: Johnson, Bryan A., et al.
Publicado: (2022)

Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis
por: Johnson, Bryan A., et al.
Publicado: (2022)

IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA
por: Fleith, Renata C, et al.
Publicado: (2018)

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members
por: Daffis, Stephane, et al.
Publicado: (2010)

Inhibition of Proteasome Activity Induces Aggregation of IFIT2 in the Centrosome and Enhances IFIT2-Induced Cell Apoptosis
por: Chen, Limin, et al.
Publicado: (2017)

The N501Y spike substitution enhances SARS-CoV-2 transmission
por: Liu, Yang, et al.
Publicado: (2021)

COL8A1 Promotes NSCLC Progression Through IFIT1/IFIT3-Mediated EGFR Activation
por: Zan, Xiangyi, et al.
Publicado: (2022)

Emerging Functions of Human IFIT Proteins in Cancer
por: Pidugu, Vijaya Kumar, et al.
Publicado: (2019)

How Different Pathologies Are Affected by IFIT Expression
por: Franco, Justin H., et al.
Publicado: (2023)

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
por: Shi, Pei-Yong, et al.
Publicado: (2020)

Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge
por: Muruato, Antonio, et al.
Publicado: (2021)

IFITs: Emerging Roles as Key Anti-Viral Proteins
por: Vladimer, Gregory I., et al.
Publicado: (2014)

The broad-spectrum antiviral functions of IFIT and IFITM proteins
por: Diamond, Michael S., et al.
Publicado: (2012)

Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics
por: Miedziak, Beata, et al.
Publicado: (2020)

LncRNA RP5-998N21.4 promotes immune defense through upregulation of IFIT2 and IFIT3 in schizophrenia
por: Guo, Bo, et al.
Publicado: (2022)

Lysyl oxidase‐like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3
por: Lu, Yi‐Jie, et al.
Publicado: (2023)

Understanding Flavivirus Capsid Protein Functions: The Tip of the Iceberg
por: Sotcheff, Stephanea, et al.
Publicado: (2020)

Mouse Ifit1b is a cap1-RNA–binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c
por: Mears, Harriet V., et al.
Publicado: (2020)

Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals
por: Daugherty, Matthew D, et al.
Publicado: (2016)

Identification and Validation of Ifit1 as an Important Innate Immune Bottleneck
por: McDermott, Jason E., et al.
Publicado: (2012)

Interferon Induced IFIT Family Genes in Host Antiviral Defense
por: Zhou, Xiang, et al.
Publicado: (2013)

I19 Antiviral actions of the interferon-inducible IFIT proteins
por: Sen, G.
Publicado: (2012)

Molecular identification and transcriptional regulation of porcine IFIT2 gene
por: Yang, Xiuqin, et al.
Publicado: (2018)

The variant gambit: COVID-19’s next move
por: Plante, Jessica A., et al.
Publicado: (2021)

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
por: Plante, Jessica A., et al.
Publicado: (2020)

Author Correction: Spike mutation D614G alters SARS-CoV-2 fitness
por: Plante, Jessica A., et al.
Publicado: (2021)

PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2
por: Shen, Hui, et al.
Publicado: (2018)

Clinical significance of IFIT2 expression in human renal cancer tissues
por: Xu, Bin, et al.
Publicado: (2020)

Increased Interferon-Induced Protein With Tetracopeptides (IFITs) Reduces Mycobacterial Growth
por: Madhvi, Abhilasha, et al.
Publicado: (2022)

IFIT3 and IFIT5 Play Potential Roles in Innate Immune Response of Porcine Pulmonary Microvascular Endothelial Cells to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus
por: Wu, Yanmei, et al.
Publicado: (2022)

2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo
por: Szretter, Kristy J., et al.
Publicado: (2012)

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis
por: Johnson, Bryan A., et al.
Publicado: (2020)

Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge
por: Muruato, Antonio, et al.
Publicado: (2021)

Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA
por: Habjan, Matthias, et al.
Publicado: (2013)

Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins
por: Abbas, Yazan M., et al.
Publicado: (2013)

IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells
por: Chico, Veronica, et al.
Publicado: (2019)

The roles and mechanism of IFIT5 in bladder cancer epithelial–mesenchymal transition and progression
por: Huang, Jun, et al.
Publicado: (2019)

Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection
por: Kimura, Taishi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ksvaton95ej2s1tuiu4jgth09k