IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding

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The constant domains of antibodies are important for effector functions, but less is known about how they can affect binding and neutralization of viruses. Here we evaluated a panel of human influenza virus monoclonal antibodies (mAbs) expressed as IgG1, IgG2 or IgG3. We found that many influenza vi...

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Detalles Bibliográficos
Autores principales: Bolton, Marcus J., Arevalo, Claudia P., Griesman, Trevor, Li, Shuk Hang, Bates, Paul, Wilson, Patrick C., Hensley, Scott E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536032/
https://www.ncbi.nlm.nih.gov/pubmed/36203556
http://dx.doi.org/10.1101/2022.09.27.509738
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