High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike

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Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to stabilize its prefusion conformation. However, contemporary methods on engineering prefusion-stabilized spike immunogens...

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Detalles Bibliográficos
Autores principales: Tan, Timothy J.C., Mou, Zongjun, Lei, Ruipeng, Ouyang, Wenhao O., Yuan, Meng, Song, Ge, Andrabi, Raiees, Wilson, Ian A., Kieffer, Collin, Dai, Xinghong, Matreyek, Kenneth A., Wu, Nicholas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536033/
https://www.ncbi.nlm.nih.gov/pubmed/36203547
http://dx.doi.org/10.1101/2022.09.24.509341
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