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Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis

We report here a case of sternoclavicular arthritis due to SAPHO syndrome in a 60-year-old female in which quantitative values determined using bone SPECT/CT were useful to evaluate response. After celecoxib and alendronate sodium hydrate therapy, the chief complaints were well relieved and post-tre...

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Autores principales: Komoto, Hisashi, Kitajima, Kazuhiro, Azuma, Naoto, Tamura, Masao, Yokoyama, Hiroyuki, Tsuchitani, Tatsuya, Yamakado, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536095/
https://www.ncbi.nlm.nih.gov/pubmed/36213208
http://dx.doi.org/10.1177/20584601221128409
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author Komoto, Hisashi
Kitajima, Kazuhiro
Azuma, Naoto
Tamura, Masao
Yokoyama, Hiroyuki
Tsuchitani, Tatsuya
Yamakado, Koichiro
author_facet Komoto, Hisashi
Kitajima, Kazuhiro
Azuma, Naoto
Tamura, Masao
Yokoyama, Hiroyuki
Tsuchitani, Tatsuya
Yamakado, Koichiro
author_sort Komoto, Hisashi
collection PubMed
description We report here a case of sternoclavicular arthritis due to SAPHO syndrome in a 60-year-old female in which quantitative values determined using bone SPECT/CT were useful to evaluate response. After celecoxib and alendronate sodium hydrate therapy, the chief complaints were well relieved and post-treatment Tc-99m HMDP bone SPECT/CT examination showed decreased uptake. The maximum standardized uptake value (SUV), peak SUV, mean SUV, metabolic bone volume, and total bone uptake of the untreated lesion were 18, 16, 10, 17 mL, and 180, respectively, which were decreased to 8, 7, 5, 15 mL, and 75, respectively, after the treatment. In comparison with pre-treatment situation, those parameters were decreased by −56%, −56%, −50%, −12%, and −58%, respectively, following celecoxib and alendronate sodium hydrate therapy, likely reflecting treatment response. Quantitative bone SPECT/CT may be useful to evaluate joint inflammatory activity and treatment response in a patient with osteoartritis.
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spelling pubmed-95360952022-10-07 Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis Komoto, Hisashi Kitajima, Kazuhiro Azuma, Naoto Tamura, Masao Yokoyama, Hiroyuki Tsuchitani, Tatsuya Yamakado, Koichiro Acta Radiol Open Case Report We report here a case of sternoclavicular arthritis due to SAPHO syndrome in a 60-year-old female in which quantitative values determined using bone SPECT/CT were useful to evaluate response. After celecoxib and alendronate sodium hydrate therapy, the chief complaints were well relieved and post-treatment Tc-99m HMDP bone SPECT/CT examination showed decreased uptake. The maximum standardized uptake value (SUV), peak SUV, mean SUV, metabolic bone volume, and total bone uptake of the untreated lesion were 18, 16, 10, 17 mL, and 180, respectively, which were decreased to 8, 7, 5, 15 mL, and 75, respectively, after the treatment. In comparison with pre-treatment situation, those parameters were decreased by −56%, −56%, −50%, −12%, and −58%, respectively, following celecoxib and alendronate sodium hydrate therapy, likely reflecting treatment response. Quantitative bone SPECT/CT may be useful to evaluate joint inflammatory activity and treatment response in a patient with osteoartritis. SAGE Publications 2022-10-04 /pmc/articles/PMC9536095/ /pubmed/36213208 http://dx.doi.org/10.1177/20584601221128409 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Komoto, Hisashi
Kitajima, Kazuhiro
Azuma, Naoto
Tamura, Masao
Yokoyama, Hiroyuki
Tsuchitani, Tatsuya
Yamakado, Koichiro
Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis
title Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis
title_full Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis
title_fullStr Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis
title_full_unstemmed Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis
title_short Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis
title_sort quantitative bone spect/ct for evaluating treatment response in patient with sternoclavicular arthritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536095/
https://www.ncbi.nlm.nih.gov/pubmed/36213208
http://dx.doi.org/10.1177/20584601221128409
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