Affinity maturation of TCR-like antibodies using phage display guided by structural modeling

TCR-like antibodies represent a unique type of engineered antibodies with specificity toward pHLA, a ligand normally restricted to the sensitive recognition by T cells. Here, we report a phage display-based sequential development path of such antibodies. The strategy goes from initial lead identific...

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Detalles Bibliográficos
Autores principales: Frick, Rahel, Høydahl, Lene S, Hodnebrug, Ina, Vik, Erik S, Dalhus, Bjørn, Sollid, Ludvig M, Gray, Jeffrey J, Sandlie, Inger, Løset, Geir Åge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536190/
https://www.ncbi.nlm.nih.gov/pubmed/35871543
http://dx.doi.org/10.1093/protein/gzac005

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