Murine CAR19 Tregs suppress acute graft-versus-host disease and maintain graft-versus-tumor responses

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) efficacy is complicated by graft-versus-host disease (GVHD), a leading cause of morbidity and mortality. Regulatory T cells (Tregs) have shown efficacy in preventing GVHD. However, high Treg doses are often required, necessitating substa...

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Detalles Bibliográficos
Autores principales: Bolivar-Wagers, Sara, Loschi, Michael L., Jin, Sujeong, Thangavelu, Govindarajan, Larson, Jemma H., McDonald-Hyman, Cameron S., Aguilar, Ethan G., Saha, Asim, Koehn, Brent H., Hefazi, Mehrdad, Osborn, Mark J., Jensen, Michael C., Wagner, John E., Pennell, Christopher A., Blazar, Bruce R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536261/
https://www.ncbi.nlm.nih.gov/pubmed/35917188
http://dx.doi.org/10.1172/jci.insight.160674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536261/
https://www.ncbi.nlm.nih.gov/pubmed/35917188
http://dx.doi.org/10.1172/jci.insight.160674

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