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Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c(+) myeloid-derived suppressor cells

Lysosomal acid lipase (LAL) is a key enzyme in the metabolic pathway of neutral lipids. In the blood of LAL-deficient (Lal(–/–)) mice, increased CD11c(+) cells were accompanied by upregulated programmed cell death ligand 1 (PD-L1) expression. Single-cell RNA sequencing of Lal(–/–) CD11c(+) cells ide...

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Detalles Bibliográficos
Autores principales:	Zhao, Ting, Liu, Sheng, Ding, Xinchun, Johnson, Erica M., Hanna, Nasser H., Singh, Kanhaiya, Sen, Chandan K., Wan, Jun, Du, Hong, Yan, Cong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536279/ https://www.ncbi.nlm.nih.gov/pubmed/35917184 http://dx.doi.org/10.1172/jci.insight.156623

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