Cargando…

Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c(+) myeloid-derived suppressor cells

Lysosomal acid lipase (LAL) is a key enzyme in the metabolic pathway of neutral lipids. In the blood of LAL-deficient (Lal(–/–)) mice, increased CD11c(+) cells were accompanied by upregulated programmed cell death ligand 1 (PD-L1) expression. Single-cell RNA sequencing of Lal(–/–) CD11c(+) cells ide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Ting, Liu, Sheng, Ding, Xinchun, Johnson, Erica M., Hanna, Nasser H., Singh, Kanhaiya, Sen, Chandan K., Wan, Jun, Du, Hong, Yan, Cong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536279/ https://www.ncbi.nlm.nih.gov/pubmed/35917184 http://dx.doi.org/10.1172/jci.insight.156623

Ejemplares similares

Gene Profile of Myeloid-Derived Suppressive Cells from the Bone Marrow of Lysosomal Acid Lipase Knock-Out Mice
por: Yan, Cong, et al.
Publicado: (2012)

Lysosomal acid lipase in cancer
por: Yan, Cong, et al.
Publicado: (2015)

LAL deficiency induced myeloid-derived suppressor cells as targets and biomarkers for lung cancer
por: Zhao, Ting, et al.
Publicado: (2023)

Lipases in lysosomes, what for?
por: Czaja, Mark J., et al.
Publicado: (2009)

Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade
por: Grauers Wiktorin, Hanna, et al.
Publicado: (2018)

Early Activation of Myeloid-Derived Suppressor Cells Participate in Sepsis-Induced Immune Suppression via PD-L1/PD-1 Axis
por: Ruan, Wei-Shuyi, et al.
Publicado: (2020)

Rab7 GTPase controls lipid metabolic signaling in myeloid-derived suppressor cells
por: Ding, Xinchun, et al.
Publicado: (2017)

Clinical Features of Lysosomal Acid Lipase Deficiency
por: Burton, Barbara K., et al.
Publicado: (2015)

Hepatosteatosis from Lysosomal Acid Lipase Deficiency
por: Zandanell, Stephan, et al.
Publicado: (2018)

Lysosomal Acid Lipase Deficiency: Therapeutic Options
por: Pastores, Gregory M, et al.
Publicado: (2020)

Lysosomal acid lipase in mesenchymal stem cell stimulation of tumor growth and metastasis
por: Zhao, Ting, et al.
Publicado: (2016)

Gr-1(+)CD11b(+) Myeloid-Derived Suppressor Cells: Formidable Partners in Tumor Metastasis
por: Yang, Li, et al.
Publicado: (2010)

Gr1(int)CD11b(+) Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection
por: Obregón-Henao, Andrés, et al.
Publicado: (2013)

Targeting depletion of myeloid-derived suppressor cells potentiates PD-L1 blockade efficacy in gastric and colon cancers
por: Tang, Yao, et al.
Publicado: (2022)

GM-CSF Nitration Is a New Driver of Myeloid Suppressor Cell Activity in Tumors
por: Calì, Bianca, et al.
Publicado: (2021)

HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels
por: Priceputu, Elena, et al.
Publicado: (2021)

Analysis of the Expression and Regulation of PD-1 Protein on the Surface of Myeloid-Derived Suppressor Cells (MDSCs)
por: Nam, Sorim, et al.
Publicado: (2019)

Myeloid-Derived Suppressor Cells (MDSC) in Melanoma Patients Treated with Anti-PD-1 Immunotherapy
por: Tomela, Katarzyna, et al.
Publicado: (2023)

Osteoclasts in Multiple Myeloma Are Derived from Gr-1+CD11b+Myeloid-Derived Suppressor Cells
por: Zhuang, Junling, et al.
Publicado: (2012)

Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover
por: Grumet, Lukas, et al.
Publicado: (2016)

Lysosomal acid lipase deficiency – early diagnosis is the key
por: Strebinger, Georg, et al.
Publicado: (2019)

Persistent dyslipidemia in treatment of lysosomal acid lipase deficiency
por: Pritchard, Amanda Barone, et al.
Publicado: (2020)

Progressive macrophage accumulation in lysosomal acid lipase deficiency
por: Lipiński, Patryk, et al.
Publicado: (2020)

Human fetal dermal fibroblast-myeloid cell diversity is characterized by dominance of pro-healing Annexin1-FPR1 signaling
por: Srivastava, Rajneesh, et al.
Publicado: (2023)

The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer
por: Kawano, Mahiru, et al.
Publicado: (2015)

Activation of mTOR Pathway in Myeloid-derived Suppressor Cells Stimulates Cancer Cell Proliferation and Metastasis in lal−/− Mice
por: Zhao, Ting, et al.
Publicado: (2014)

Chrysin targets myeloid‐derived suppressor cells and enhances tumour response to anti‐PD‐1 immunotherapy
por: Li, Yinan, et al.
Publicado: (2022)

Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimer’s Disease
por: Armstrong, Andrea, et al.
Publicado: (2013)

Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease
por: Nguyen, Hung D., et al.
Publicado: (2020)

G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b(+)Gr-1(+) myeloid cells without compromising CD8(+) T cell immune responses
por: Rubinstein, Mark P, et al.
Publicado: (2013)

Agonistic Anti-CD137 Monoclonal Antibody Treatment Induces CD11b(+)Gr-1(+) Myeloid-derived Suppressor Cells
por: Lee, Jung-Mi, et al.
Publicado: (2010)

Targeting GGT1 Eliminates the Tumor-Promoting Effect and Enhanced Immunosuppressive Function of Myeloid-Derived Suppressor Cells Caused by G-CSF
por: Xie, Zhiqi, et al.
Publicado: (2022)

Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism
por: Dubland, Joshua A., et al.
Publicado: (2015)

Lysosomal Acid Lipase Deficiency: Genetics, Screening, and Preclinical Study
por: Mashima, Ryuichi, et al.
Publicado: (2022)

Distinguishing Lysosomal Acid Lipase Deficiency From Familial Hypercholesterolemia
por: Sheth, Sohum, et al.
Publicado: (2023)

NAD(+) attenuates experimental autoimmune encephalomyelitis through induction of CD11b(+) gr-1(+) myeloid-derived suppressor cells
por: Wang, Jin-Li, et al.
Publicado: (2020)

Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway
por: Ding, Ying, et al.
Publicado: (2018)

Prognostic stratification based on the levels of tumor-infiltrating myeloid-derived suppressor cells and PD-1/PD-L1 axis in locally advanced rectal cancer
por: Lim, Yu Jin, et al.
Publicado: (2022)

Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells
por: Gao, Wanfeng, et al.
Publicado: (2019)

High Levels of PD-L1(+) and Hyal2(+) Myeloid-derived Suppressor Cells in Renal Cell Carcinoma
por: Kusmartsev, Sergei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ad1f9c052mts90gk1v3a84n1md