Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding

Osteosarcoma (OS) is a lethal disease with few known targeted therapies. Here, we show that decreased ATRX expression is associated with more aggressive tumor cell phenotypes, including increased growth, migration, invasion, and metastasis. These phenotypic changes correspond with activation of NF-κ...

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Detalles Bibliográficos
Autores principales: Bartholf DeWitt, Suzanne, Hoskinson Plumlee, Sarah, Brighton, Hailey E., Sivaraj, Dharshan, Martz, E.J., Zand, Maryam, Kumar, Vardhman, Sheth, Maya U., Floyd, Warren, Spruance, Jacob V., Hawkey, Nathan, Varghese, Shyni, Ruan, Jianhua, Kirsch, David G., Somarelli, Jason A., Alman, Ben, Eward, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536280/
https://www.ncbi.nlm.nih.gov/pubmed/36073547
http://dx.doi.org/10.1172/jci.insight.151583

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