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Exogenous signaling repairs defective T cell signaling inside the tumor microenvironment for better immunity

It is known that tumor-reactive T cells are initially activated in the draining lymph node, but it is not well known whether and how tumor-infiltrating lymphocytes (TILs) are reactivated in the tumor microenvironment (TME). We hypothesize that defective T cell receptor (TCR) signaling and cosignals...

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Detalles Bibliográficos
Autores principales:	Moore, Casey, Bae, Joonbeom, Liu, Longchao, Li, Huiyu, Fu, Yang-Xin, Qiao, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536281/ https://www.ncbi.nlm.nih.gov/pubmed/36073543 http://dx.doi.org/10.1172/jci.insight.159479

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