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The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy

OBJECTIVE: To investigate changes in uroflowmetry parameters in men undergoing robot-assisted radical prostatectomy (RARP) for prostate cancer. MATERIALS AND METHODS: Four hundred and twenty-eight patients received uroflowmetry testing before and after RARP from November 2011 to December 2018. Clini...

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Autores principales: Takeshima, Yuta, Yamada, Yuta, Takemura, Kotaro, Kimura, Naoki, Hakozaki, Yuji, Miyakawa, Jimpei, Taguchi, Satoru, Akiyama, Yoshiyuki, Sato, Yusuke, Kawai, Taketo, Yamada, Daisuke, Fujimura, Tetsuya, Kume, Haruki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536545/
https://www.ncbi.nlm.nih.gov/pubmed/36201466
http://dx.doi.org/10.1371/journal.pone.0275069
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author Takeshima, Yuta
Yamada, Yuta
Takemura, Kotaro
Kimura, Naoki
Hakozaki, Yuji
Miyakawa, Jimpei
Taguchi, Satoru
Akiyama, Yoshiyuki
Sato, Yusuke
Kawai, Taketo
Yamada, Daisuke
Fujimura, Tetsuya
Kume, Haruki
author_facet Takeshima, Yuta
Yamada, Yuta
Takemura, Kotaro
Kimura, Naoki
Hakozaki, Yuji
Miyakawa, Jimpei
Taguchi, Satoru
Akiyama, Yoshiyuki
Sato, Yusuke
Kawai, Taketo
Yamada, Daisuke
Fujimura, Tetsuya
Kume, Haruki
author_sort Takeshima, Yuta
collection PubMed
description OBJECTIVE: To investigate changes in uroflowmetry parameters in men undergoing robot-assisted radical prostatectomy (RARP) for prostate cancer. MATERIALS AND METHODS: Four hundred and twenty-eight patients received uroflowmetry testing before and after RARP from November 2011 to December 2018. Clinicopathological data, including age, initial prostate-specific antigen (PSA), prostate volume, clinical stage, body mass index (BMI), uroflowmetry parameters, and core lower urinary tract symptom scores (CLSS) were retrospectively obtained from clinical records. Changes in uroflowmetry parameters were analyzed for statistical predictors and effects on post-operative outcomes. RESULTS: A significant increase in maximum flow rate (MFR) and decreases in voided volume (VV) and post-void residual urine (PVR) were seen. In multivariate analysis, age was a negative predictor of MFR increase, while prostate volume was a positive predictor of PVR decrease and MFR increase. VV decrease led to worse incontinence symptoms, while PVR decrease and MFR increase led to improvement in voiding symptoms such as slow stream and straining. Continence recovery curves showed that VV decrease were associated with a delay in continence recovery. CONCLUSIONS: Significant changes were seen in uroflowmetry results after RARP, each parameter directly related to urinary symptoms. In particular, VV decrease was associated with a worsening of incontinence symptoms and continence recovery.
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spelling pubmed-95365452022-10-07 The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy Takeshima, Yuta Yamada, Yuta Takemura, Kotaro Kimura, Naoki Hakozaki, Yuji Miyakawa, Jimpei Taguchi, Satoru Akiyama, Yoshiyuki Sato, Yusuke Kawai, Taketo Yamada, Daisuke Fujimura, Tetsuya Kume, Haruki PLoS One Research Article OBJECTIVE: To investigate changes in uroflowmetry parameters in men undergoing robot-assisted radical prostatectomy (RARP) for prostate cancer. MATERIALS AND METHODS: Four hundred and twenty-eight patients received uroflowmetry testing before and after RARP from November 2011 to December 2018. Clinicopathological data, including age, initial prostate-specific antigen (PSA), prostate volume, clinical stage, body mass index (BMI), uroflowmetry parameters, and core lower urinary tract symptom scores (CLSS) were retrospectively obtained from clinical records. Changes in uroflowmetry parameters were analyzed for statistical predictors and effects on post-operative outcomes. RESULTS: A significant increase in maximum flow rate (MFR) and decreases in voided volume (VV) and post-void residual urine (PVR) were seen. In multivariate analysis, age was a negative predictor of MFR increase, while prostate volume was a positive predictor of PVR decrease and MFR increase. VV decrease led to worse incontinence symptoms, while PVR decrease and MFR increase led to improvement in voiding symptoms such as slow stream and straining. Continence recovery curves showed that VV decrease were associated with a delay in continence recovery. CONCLUSIONS: Significant changes were seen in uroflowmetry results after RARP, each parameter directly related to urinary symptoms. In particular, VV decrease was associated with a worsening of incontinence symptoms and continence recovery. Public Library of Science 2022-10-06 /pmc/articles/PMC9536545/ /pubmed/36201466 http://dx.doi.org/10.1371/journal.pone.0275069 Text en © 2022 Takeshima et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Takeshima, Yuta
Yamada, Yuta
Takemura, Kotaro
Kimura, Naoki
Hakozaki, Yuji
Miyakawa, Jimpei
Taguchi, Satoru
Akiyama, Yoshiyuki
Sato, Yusuke
Kawai, Taketo
Yamada, Daisuke
Fujimura, Tetsuya
Kume, Haruki
The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy
title The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy
title_full The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy
title_fullStr The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy
title_full_unstemmed The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy
title_short The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy
title_sort association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536545/
https://www.ncbi.nlm.nih.gov/pubmed/36201466
http://dx.doi.org/10.1371/journal.pone.0275069
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