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The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy
OBJECTIVE: To investigate changes in uroflowmetry parameters in men undergoing robot-assisted radical prostatectomy (RARP) for prostate cancer. MATERIALS AND METHODS: Four hundred and twenty-eight patients received uroflowmetry testing before and after RARP from November 2011 to December 2018. Clini...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536545/ https://www.ncbi.nlm.nih.gov/pubmed/36201466 http://dx.doi.org/10.1371/journal.pone.0275069 |
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author | Takeshima, Yuta Yamada, Yuta Takemura, Kotaro Kimura, Naoki Hakozaki, Yuji Miyakawa, Jimpei Taguchi, Satoru Akiyama, Yoshiyuki Sato, Yusuke Kawai, Taketo Yamada, Daisuke Fujimura, Tetsuya Kume, Haruki |
author_facet | Takeshima, Yuta Yamada, Yuta Takemura, Kotaro Kimura, Naoki Hakozaki, Yuji Miyakawa, Jimpei Taguchi, Satoru Akiyama, Yoshiyuki Sato, Yusuke Kawai, Taketo Yamada, Daisuke Fujimura, Tetsuya Kume, Haruki |
author_sort | Takeshima, Yuta |
collection | PubMed |
description | OBJECTIVE: To investigate changes in uroflowmetry parameters in men undergoing robot-assisted radical prostatectomy (RARP) for prostate cancer. MATERIALS AND METHODS: Four hundred and twenty-eight patients received uroflowmetry testing before and after RARP from November 2011 to December 2018. Clinicopathological data, including age, initial prostate-specific antigen (PSA), prostate volume, clinical stage, body mass index (BMI), uroflowmetry parameters, and core lower urinary tract symptom scores (CLSS) were retrospectively obtained from clinical records. Changes in uroflowmetry parameters were analyzed for statistical predictors and effects on post-operative outcomes. RESULTS: A significant increase in maximum flow rate (MFR) and decreases in voided volume (VV) and post-void residual urine (PVR) were seen. In multivariate analysis, age was a negative predictor of MFR increase, while prostate volume was a positive predictor of PVR decrease and MFR increase. VV decrease led to worse incontinence symptoms, while PVR decrease and MFR increase led to improvement in voiding symptoms such as slow stream and straining. Continence recovery curves showed that VV decrease were associated with a delay in continence recovery. CONCLUSIONS: Significant changes were seen in uroflowmetry results after RARP, each parameter directly related to urinary symptoms. In particular, VV decrease was associated with a worsening of incontinence symptoms and continence recovery. |
format | Online Article Text |
id | pubmed-9536545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-95365452022-10-07 The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy Takeshima, Yuta Yamada, Yuta Takemura, Kotaro Kimura, Naoki Hakozaki, Yuji Miyakawa, Jimpei Taguchi, Satoru Akiyama, Yoshiyuki Sato, Yusuke Kawai, Taketo Yamada, Daisuke Fujimura, Tetsuya Kume, Haruki PLoS One Research Article OBJECTIVE: To investigate changes in uroflowmetry parameters in men undergoing robot-assisted radical prostatectomy (RARP) for prostate cancer. MATERIALS AND METHODS: Four hundred and twenty-eight patients received uroflowmetry testing before and after RARP from November 2011 to December 2018. Clinicopathological data, including age, initial prostate-specific antigen (PSA), prostate volume, clinical stage, body mass index (BMI), uroflowmetry parameters, and core lower urinary tract symptom scores (CLSS) were retrospectively obtained from clinical records. Changes in uroflowmetry parameters were analyzed for statistical predictors and effects on post-operative outcomes. RESULTS: A significant increase in maximum flow rate (MFR) and decreases in voided volume (VV) and post-void residual urine (PVR) were seen. In multivariate analysis, age was a negative predictor of MFR increase, while prostate volume was a positive predictor of PVR decrease and MFR increase. VV decrease led to worse incontinence symptoms, while PVR decrease and MFR increase led to improvement in voiding symptoms such as slow stream and straining. Continence recovery curves showed that VV decrease were associated with a delay in continence recovery. CONCLUSIONS: Significant changes were seen in uroflowmetry results after RARP, each parameter directly related to urinary symptoms. In particular, VV decrease was associated with a worsening of incontinence symptoms and continence recovery. Public Library of Science 2022-10-06 /pmc/articles/PMC9536545/ /pubmed/36201466 http://dx.doi.org/10.1371/journal.pone.0275069 Text en © 2022 Takeshima et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Takeshima, Yuta Yamada, Yuta Takemura, Kotaro Kimura, Naoki Hakozaki, Yuji Miyakawa, Jimpei Taguchi, Satoru Akiyama, Yoshiyuki Sato, Yusuke Kawai, Taketo Yamada, Daisuke Fujimura, Tetsuya Kume, Haruki The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy |
title | The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy |
title_full | The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy |
title_fullStr | The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy |
title_full_unstemmed | The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy |
title_short | The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy |
title_sort | association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536545/ https://www.ncbi.nlm.nih.gov/pubmed/36201466 http://dx.doi.org/10.1371/journal.pone.0275069 |
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