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Chromoblastomycosis: A case series from Eastern China
Chromoblastomycosis (CBM) is a chronic fungal infection of the cutaneous and subcutaneous tissues caused by brown pigmented fungi. Fonsecaea monophora is one of the most common pathogens of CBM in China. Most formal cases have been reported from Southern China, however, the infection is not uncommon...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536625/ https://www.ncbi.nlm.nih.gov/pubmed/36155495 http://dx.doi.org/10.1371/journal.pntd.0010800 |
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author | Liu, Sujun Zhi, Huilin Shen, Hong Lv, Wenwen Sang, Bo Li, Qiuping Zhong, Yan Liu, Zehu Xia, Xiujiao |
author_facet | Liu, Sujun Zhi, Huilin Shen, Hong Lv, Wenwen Sang, Bo Li, Qiuping Zhong, Yan Liu, Zehu Xia, Xiujiao |
author_sort | Liu, Sujun |
collection | PubMed |
description | Chromoblastomycosis (CBM) is a chronic fungal infection of the cutaneous and subcutaneous tissues caused by brown pigmented fungi. Fonsecaea monophora is one of the most common pathogens of CBM in China. Most formal cases have been reported from Southern China, however, the infection is not uncommon in Eastern China where very few case series are available. To describe the clinical aspects of CBM, we report a series of 11 cases between 2018 and 2021 at a single medical center in Eastern China. The patients were predominately male (n = 9) and the disease duration ranged from 3 months to 20 years. Plaque type lesions were the most common clinical manifestations. There were 7 cases of mild forms and 3 cases of severe forms. Among the 3 severe cases, one case gave up treatment due to economic poverty; one case did not respond to a 1-year systemic treatmen; one case was cured by combination therapy of 10 months. Other cases were cured by treatment with antifungal agents. All cases of direct mycological examination were positive. All isolates were identified by morphology and sequencing of the the ITS regions of ribosomal DNA, Ten were F. monophora and 1 was Cladophialophora carrionii. All cases had been evaluated at other clinics, where 8 cases were misdiagnosed as other diseases. As a neglected tropical disease (NTD), CBM is still a major challenge in the field of dermatology, especially in its severe clinical forms. As an effective and simple diagnostic method of CBM, direct microscopic examination should be further promoted in rural hospitals. |
format | Online Article Text |
id | pubmed-9536625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-95366252022-10-07 Chromoblastomycosis: A case series from Eastern China Liu, Sujun Zhi, Huilin Shen, Hong Lv, Wenwen Sang, Bo Li, Qiuping Zhong, Yan Liu, Zehu Xia, Xiujiao PLoS Negl Trop Dis Research Article Chromoblastomycosis (CBM) is a chronic fungal infection of the cutaneous and subcutaneous tissues caused by brown pigmented fungi. Fonsecaea monophora is one of the most common pathogens of CBM in China. Most formal cases have been reported from Southern China, however, the infection is not uncommon in Eastern China where very few case series are available. To describe the clinical aspects of CBM, we report a series of 11 cases between 2018 and 2021 at a single medical center in Eastern China. The patients were predominately male (n = 9) and the disease duration ranged from 3 months to 20 years. Plaque type lesions were the most common clinical manifestations. There were 7 cases of mild forms and 3 cases of severe forms. Among the 3 severe cases, one case gave up treatment due to economic poverty; one case did not respond to a 1-year systemic treatmen; one case was cured by combination therapy of 10 months. Other cases were cured by treatment with antifungal agents. All cases of direct mycological examination were positive. All isolates were identified by morphology and sequencing of the the ITS regions of ribosomal DNA, Ten were F. monophora and 1 was Cladophialophora carrionii. All cases had been evaluated at other clinics, where 8 cases were misdiagnosed as other diseases. As a neglected tropical disease (NTD), CBM is still a major challenge in the field of dermatology, especially in its severe clinical forms. As an effective and simple diagnostic method of CBM, direct microscopic examination should be further promoted in rural hospitals. Public Library of Science 2022-09-26 /pmc/articles/PMC9536625/ /pubmed/36155495 http://dx.doi.org/10.1371/journal.pntd.0010800 Text en © 2022 Liu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Liu, Sujun Zhi, Huilin Shen, Hong Lv, Wenwen Sang, Bo Li, Qiuping Zhong, Yan Liu, Zehu Xia, Xiujiao Chromoblastomycosis: A case series from Eastern China |
title | Chromoblastomycosis: A case series from Eastern China |
title_full | Chromoblastomycosis: A case series from Eastern China |
title_fullStr | Chromoblastomycosis: A case series from Eastern China |
title_full_unstemmed | Chromoblastomycosis: A case series from Eastern China |
title_short | Chromoblastomycosis: A case series from Eastern China |
title_sort | chromoblastomycosis: a case series from eastern china |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536625/ https://www.ncbi.nlm.nih.gov/pubmed/36155495 http://dx.doi.org/10.1371/journal.pntd.0010800 |
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