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Chromoblastomycosis: A case series from Eastern China

Chromoblastomycosis (CBM) is a chronic fungal infection of the cutaneous and subcutaneous tissues caused by brown pigmented fungi. Fonsecaea monophora is one of the most common pathogens of CBM in China. Most formal cases have been reported from Southern China, however, the infection is not uncommon...

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Autores principales: Liu, Sujun, Zhi, Huilin, Shen, Hong, Lv, Wenwen, Sang, Bo, Li, Qiuping, Zhong, Yan, Liu, Zehu, Xia, Xiujiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536625/
https://www.ncbi.nlm.nih.gov/pubmed/36155495
http://dx.doi.org/10.1371/journal.pntd.0010800
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author Liu, Sujun
Zhi, Huilin
Shen, Hong
Lv, Wenwen
Sang, Bo
Li, Qiuping
Zhong, Yan
Liu, Zehu
Xia, Xiujiao
author_facet Liu, Sujun
Zhi, Huilin
Shen, Hong
Lv, Wenwen
Sang, Bo
Li, Qiuping
Zhong, Yan
Liu, Zehu
Xia, Xiujiao
author_sort Liu, Sujun
collection PubMed
description Chromoblastomycosis (CBM) is a chronic fungal infection of the cutaneous and subcutaneous tissues caused by brown pigmented fungi. Fonsecaea monophora is one of the most common pathogens of CBM in China. Most formal cases have been reported from Southern China, however, the infection is not uncommon in Eastern China where very few case series are available. To describe the clinical aspects of CBM, we report a series of 11 cases between 2018 and 2021 at a single medical center in Eastern China. The patients were predominately male (n = 9) and the disease duration ranged from 3 months to 20 years. Plaque type lesions were the most common clinical manifestations. There were 7 cases of mild forms and 3 cases of severe forms. Among the 3 severe cases, one case gave up treatment due to economic poverty; one case did not respond to a 1-year systemic treatmen; one case was cured by combination therapy of 10 months. Other cases were cured by treatment with antifungal agents. All cases of direct mycological examination were positive. All isolates were identified by morphology and sequencing of the the ITS regions of ribosomal DNA, Ten were F. monophora and 1 was Cladophialophora carrionii. All cases had been evaluated at other clinics, where 8 cases were misdiagnosed as other diseases. As a neglected tropical disease (NTD), CBM is still a major challenge in the field of dermatology, especially in its severe clinical forms. As an effective and simple diagnostic method of CBM, direct microscopic examination should be further promoted in rural hospitals.
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spelling pubmed-95366252022-10-07 Chromoblastomycosis: A case series from Eastern China Liu, Sujun Zhi, Huilin Shen, Hong Lv, Wenwen Sang, Bo Li, Qiuping Zhong, Yan Liu, Zehu Xia, Xiujiao PLoS Negl Trop Dis Research Article Chromoblastomycosis (CBM) is a chronic fungal infection of the cutaneous and subcutaneous tissues caused by brown pigmented fungi. Fonsecaea monophora is one of the most common pathogens of CBM in China. Most formal cases have been reported from Southern China, however, the infection is not uncommon in Eastern China where very few case series are available. To describe the clinical aspects of CBM, we report a series of 11 cases between 2018 and 2021 at a single medical center in Eastern China. The patients were predominately male (n = 9) and the disease duration ranged from 3 months to 20 years. Plaque type lesions were the most common clinical manifestations. There were 7 cases of mild forms and 3 cases of severe forms. Among the 3 severe cases, one case gave up treatment due to economic poverty; one case did not respond to a 1-year systemic treatmen; one case was cured by combination therapy of 10 months. Other cases were cured by treatment with antifungal agents. All cases of direct mycological examination were positive. All isolates were identified by morphology and sequencing of the the ITS regions of ribosomal DNA, Ten were F. monophora and 1 was Cladophialophora carrionii. All cases had been evaluated at other clinics, where 8 cases were misdiagnosed as other diseases. As a neglected tropical disease (NTD), CBM is still a major challenge in the field of dermatology, especially in its severe clinical forms. As an effective and simple diagnostic method of CBM, direct microscopic examination should be further promoted in rural hospitals. Public Library of Science 2022-09-26 /pmc/articles/PMC9536625/ /pubmed/36155495 http://dx.doi.org/10.1371/journal.pntd.0010800 Text en © 2022 Liu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Liu, Sujun
Zhi, Huilin
Shen, Hong
Lv, Wenwen
Sang, Bo
Li, Qiuping
Zhong, Yan
Liu, Zehu
Xia, Xiujiao
Chromoblastomycosis: A case series from Eastern China
title Chromoblastomycosis: A case series from Eastern China
title_full Chromoblastomycosis: A case series from Eastern China
title_fullStr Chromoblastomycosis: A case series from Eastern China
title_full_unstemmed Chromoblastomycosis: A case series from Eastern China
title_short Chromoblastomycosis: A case series from Eastern China
title_sort chromoblastomycosis: a case series from eastern china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536625/
https://www.ncbi.nlm.nih.gov/pubmed/36155495
http://dx.doi.org/10.1371/journal.pntd.0010800
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