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Building an integrated serosurveillance platform to inform public health interventions: Insights from an experts’ meeting on serum biomarkers

The use of biomarkers to measure immune responses in serum is crucial for understanding population-level exposure and susceptibility to human pathogens. Advances in sample collection, multiplex testing, and computational modeling are transforming serosurveillance into a powerful tool for public heal...

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Detalles Bibliográficos
Autores principales: Wiens, Kirsten E., Jauregui, Barbara, Arnold, Benjamin F., Banke, Kathryn, Wade, Djibril, Hayford, Kyla, Costero-Saint Denis, Adriana, Hall, Robert H., Salje, Henrik, Rodriguez-Barraquer, Isabel, Azman, Andrew S., Vernet, Guy, Leung, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536637/
https://www.ncbi.nlm.nih.gov/pubmed/36201428
http://dx.doi.org/10.1371/journal.pntd.0010657
Descripción
Sumario:The use of biomarkers to measure immune responses in serum is crucial for understanding population-level exposure and susceptibility to human pathogens. Advances in sample collection, multiplex testing, and computational modeling are transforming serosurveillance into a powerful tool for public health program design and response to infectious threats. In July 2018, 70 scientists from 16 countries met to perform a landscape analysis of approaches that support an integrated serosurveillance platform, including the consideration of issues for successful implementation. Here, we summarize the group’s insights and proposed roadmap for implementation, including objectives, technical requirements, ethical issues, logistical considerations, and monitoring and evaluation.