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Understanding Obesity-Related High Output Heart Failure and Its Implications

Morbid obesity remains most common cause of high output failure. The prevalence of the obesity is growing when two-thirds of American adults already are overweight or obese. Obesity is the risk factor for heart disease and eventually leads to heart failure. High output heart failure is common in obe...

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Autores principales: Shen, Qiuhua, Hiebert, John B., Rahman, Faith K., Krueger, Kathryn J., Gupta, Bhanu, Pierce, Janet D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Heart Failure 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536652/
https://www.ncbi.nlm.nih.gov/pubmed/36262639
http://dx.doi.org/10.36628/ijhf.2020.0047
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author Shen, Qiuhua
Hiebert, John B.
Rahman, Faith K.
Krueger, Kathryn J.
Gupta, Bhanu
Pierce, Janet D.
author_facet Shen, Qiuhua
Hiebert, John B.
Rahman, Faith K.
Krueger, Kathryn J.
Gupta, Bhanu
Pierce, Janet D.
author_sort Shen, Qiuhua
collection PubMed
description Morbid obesity remains most common cause of high output failure. The prevalence of the obesity is growing when two-thirds of American adults already are overweight or obese. Obesity is the risk factor for heart disease and eventually leads to heart failure. High output heart failure is common in obese patients and is characterized by high cardiac output, decreased systemic vascular resistance, and increased oxygen consumption. It often occurs in patients with chronic severe anemia, hyperthyroidism, pregnancy, arterial-venous fistulas, and liver disease. However, the pathogenesis of obesity-related high output heart failure is not fully understood. The clinical management of obesity-related high output heart failure follows conventional heart failure regimens due to lack of specific clinical recommendations. This article reviews the possible pathophysiological mechanisms and causes that contribute to obesity-related high output heart failure. This review also focuses on the implications for clinical practice and future research involved with omics technologies to explore possible molecular pathways associated with obesity-related high output heart failure.
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spelling pubmed-95366522022-10-18 Understanding Obesity-Related High Output Heart Failure and Its Implications Shen, Qiuhua Hiebert, John B. Rahman, Faith K. Krueger, Kathryn J. Gupta, Bhanu Pierce, Janet D. Int J Heart Fail Review Article Morbid obesity remains most common cause of high output failure. The prevalence of the obesity is growing when two-thirds of American adults already are overweight or obese. Obesity is the risk factor for heart disease and eventually leads to heart failure. High output heart failure is common in obese patients and is characterized by high cardiac output, decreased systemic vascular resistance, and increased oxygen consumption. It often occurs in patients with chronic severe anemia, hyperthyroidism, pregnancy, arterial-venous fistulas, and liver disease. However, the pathogenesis of obesity-related high output heart failure is not fully understood. The clinical management of obesity-related high output heart failure follows conventional heart failure regimens due to lack of specific clinical recommendations. This article reviews the possible pathophysiological mechanisms and causes that contribute to obesity-related high output heart failure. This review also focuses on the implications for clinical practice and future research involved with omics technologies to explore possible molecular pathways associated with obesity-related high output heart failure. Korean Society of Heart Failure 2021-01-13 /pmc/articles/PMC9536652/ /pubmed/36262639 http://dx.doi.org/10.36628/ijhf.2020.0047 Text en Copyright © 2021. Korean Society of Heart Failure https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shen, Qiuhua
Hiebert, John B.
Rahman, Faith K.
Krueger, Kathryn J.
Gupta, Bhanu
Pierce, Janet D.
Understanding Obesity-Related High Output Heart Failure and Its Implications
title Understanding Obesity-Related High Output Heart Failure and Its Implications
title_full Understanding Obesity-Related High Output Heart Failure and Its Implications
title_fullStr Understanding Obesity-Related High Output Heart Failure and Its Implications
title_full_unstemmed Understanding Obesity-Related High Output Heart Failure and Its Implications
title_short Understanding Obesity-Related High Output Heart Failure and Its Implications
title_sort understanding obesity-related high output heart failure and its implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536652/
https://www.ncbi.nlm.nih.gov/pubmed/36262639
http://dx.doi.org/10.36628/ijhf.2020.0047
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