Evolution of SIVmac239 following serial passaging in humanized mice

Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross‐species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4...

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Autores principales: Curlin, James Z., Schmitt, Kimberly, Remling‐Mulder, Leila, Morrison, Jared, Baczenas, John J., Tibbits, Corina Valencia, Goff, Kelly, O'Connor, Shelby, Stenglein, Mark, Marx, Preston, Akkina, Ramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536747/
https://www.ncbi.nlm.nih.gov/pubmed/36030392
http://dx.doi.org/10.1111/jmp.12614
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author Curlin, James Z.
Schmitt, Kimberly
Remling‐Mulder, Leila
Morrison, Jared
Baczenas, John J.
Tibbits, Corina Valencia
Goff, Kelly
O'Connor, Shelby
Stenglein, Mark
Marx, Preston
Akkina, Ramesh
author_facet Curlin, James Z.
Schmitt, Kimberly
Remling‐Mulder, Leila
Morrison, Jared
Baczenas, John J.
Tibbits, Corina Valencia
Goff, Kelly
O'Connor, Shelby
Stenglein, Mark
Marx, Preston
Akkina, Ramesh
author_sort Curlin, James Z.
collection PubMed
description Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross‐species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4(+) T cell decline and increases in plasma viral loads.
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spelling pubmed-95367472022-10-14 Evolution of SIVmac239 following serial passaging in humanized mice Curlin, James Z. Schmitt, Kimberly Remling‐Mulder, Leila Morrison, Jared Baczenas, John J. Tibbits, Corina Valencia Goff, Kelly O'Connor, Shelby Stenglein, Mark Marx, Preston Akkina, Ramesh J Med Primatol Short Reports Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross‐species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4(+) T cell decline and increases in plasma viral loads. John Wiley and Sons Inc. 2022-08-28 2022-10 /pmc/articles/PMC9536747/ /pubmed/36030392 http://dx.doi.org/10.1111/jmp.12614 Text en © 2022 The Authors. Journal of Medical Primatology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Short Reports
Curlin, James Z.
Schmitt, Kimberly
Remling‐Mulder, Leila
Morrison, Jared
Baczenas, John J.
Tibbits, Corina Valencia
Goff, Kelly
O'Connor, Shelby
Stenglein, Mark
Marx, Preston
Akkina, Ramesh
Evolution of SIVmac239 following serial passaging in humanized mice
title Evolution of SIVmac239 following serial passaging in humanized mice
title_full Evolution of SIVmac239 following serial passaging in humanized mice
title_fullStr Evolution of SIVmac239 following serial passaging in humanized mice
title_full_unstemmed Evolution of SIVmac239 following serial passaging in humanized mice
title_short Evolution of SIVmac239 following serial passaging in humanized mice
title_sort evolution of sivmac239 following serial passaging in humanized mice
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536747/
https://www.ncbi.nlm.nih.gov/pubmed/36030392
http://dx.doi.org/10.1111/jmp.12614
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