Long‐term evolutionary adaptation of SIVcpz toward HIV‐1 using a humanized mouse model

Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV‐1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV‐1 Group M over the course of four generations. Higher initial viral load, increased CD4(+) T‐cell decline, and nonsynonymous su...

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Autores principales: Schmitt, Kimberly, Curlin, James, Remling‐Mulder, Leila, Morrison, Jared, Moriarty, Ryan, Goff, Kelly, Stenglein, Mark, O'Connor, Shelby, Marx, Preston, Akkina, Ramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536748/
https://www.ncbi.nlm.nih.gov/pubmed/36030391
http://dx.doi.org/10.1111/jmp.12616
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author Schmitt, Kimberly
Curlin, James
Remling‐Mulder, Leila
Morrison, Jared
Moriarty, Ryan
Goff, Kelly
Stenglein, Mark
O'Connor, Shelby
Marx, Preston
Akkina, Ramesh
author_facet Schmitt, Kimberly
Curlin, James
Remling‐Mulder, Leila
Morrison, Jared
Moriarty, Ryan
Goff, Kelly
Stenglein, Mark
O'Connor, Shelby
Marx, Preston
Akkina, Ramesh
author_sort Schmitt, Kimberly
collection PubMed
description Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV‐1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV‐1 Group M over the course of four generations. Higher initial viral load, increased CD4(+) T‐cell decline, and nonsynonymous substitutions arose suggesting viral evolution.
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spelling pubmed-95367482022-10-14 Long‐term evolutionary adaptation of SIVcpz toward HIV‐1 using a humanized mouse model Schmitt, Kimberly Curlin, James Remling‐Mulder, Leila Morrison, Jared Moriarty, Ryan Goff, Kelly Stenglein, Mark O'Connor, Shelby Marx, Preston Akkina, Ramesh J Med Primatol Short Reports Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV‐1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV‐1 Group M over the course of four generations. Higher initial viral load, increased CD4(+) T‐cell decline, and nonsynonymous substitutions arose suggesting viral evolution. John Wiley and Sons Inc. 2022-08-28 2022-10 /pmc/articles/PMC9536748/ /pubmed/36030391 http://dx.doi.org/10.1111/jmp.12616 Text en © 2022 The Authors. Journal of Medical Primatology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Short Reports
Schmitt, Kimberly
Curlin, James
Remling‐Mulder, Leila
Morrison, Jared
Moriarty, Ryan
Goff, Kelly
Stenglein, Mark
O'Connor, Shelby
Marx, Preston
Akkina, Ramesh
Long‐term evolutionary adaptation of SIVcpz toward HIV‐1 using a humanized mouse model
title Long‐term evolutionary adaptation of SIVcpz toward HIV‐1 using a humanized mouse model
title_full Long‐term evolutionary adaptation of SIVcpz toward HIV‐1 using a humanized mouse model
title_fullStr Long‐term evolutionary adaptation of SIVcpz toward HIV‐1 using a humanized mouse model
title_full_unstemmed Long‐term evolutionary adaptation of SIVcpz toward HIV‐1 using a humanized mouse model
title_short Long‐term evolutionary adaptation of SIVcpz toward HIV‐1 using a humanized mouse model
title_sort long‐term evolutionary adaptation of sivcpz toward hiv‐1 using a humanized mouse model
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536748/
https://www.ncbi.nlm.nih.gov/pubmed/36030391
http://dx.doi.org/10.1111/jmp.12616
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