Long‐term evolutionary adaptation of SIVcpz toward HIV‐1 using a humanized mouse model

Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV‐1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV‐1 Group M over the course of four generations. Higher initial viral load, increased CD4(+) T‐cell decline, and nonsynonymous su...

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Detalles Bibliográficos
Autores principales: Schmitt, Kimberly, Curlin, James, Remling‐Mulder, Leila, Morrison, Jared, Moriarty, Ryan, Goff, Kelly, Stenglein, Mark, O'Connor, Shelby, Marx, Preston, Akkina, Ramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536748/
https://www.ncbi.nlm.nih.gov/pubmed/36030391
http://dx.doi.org/10.1111/jmp.12616

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