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Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation
T cells use kinetic proofreading to discriminate antigens by converting small changes in antigen-binding lifetime into large differences in cell activation, but where in the signaling cascade this computation is performed is unknown. Previously, we developed a light-gated immune receptor to probe th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536835/ https://www.ncbi.nlm.nih.gov/pubmed/36125261 http://dx.doi.org/10.7554/eLife.75263 |