A Case of New Delhi Metallo-β-Lactamases (NDM) Citrobacter sedlakii Osteomyelitis Successfully Treated With Ceftazidime-Avibactam and Aztreonam

There have been an increase in multi-drug resistant (MDR) organisms causing infections with high mortality and morbidity. Bacteria that carry metallo-β-lactamases (MBLs) are particularly dangerous. Novel antibiotic combinations, such as ceftazidime-avibactam with aztreonam, are in clinical trials fo...

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Detalles Bibliográficos
Autores principales: Rubnitz, Zachary A, Kunkel, Victoria N, Baselski, Vickie S, Summers, Nathan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536843/
https://www.ncbi.nlm.nih.gov/pubmed/36225496
http://dx.doi.org/10.7759/cureus.28855
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author Rubnitz, Zachary A
Kunkel, Victoria N
Baselski, Vickie S
Summers, Nathan A
author_facet Rubnitz, Zachary A
Kunkel, Victoria N
Baselski, Vickie S
Summers, Nathan A
author_sort Rubnitz, Zachary A
collection PubMed
description There have been an increase in multi-drug resistant (MDR) organisms causing infections with high mortality and morbidity. Bacteria that carry metallo-β-lactamases (MBLs) are particularly dangerous. Novel antibiotic combinations, such as ceftazidime-avibactam with aztreonam, are in clinical trials for the treatment of MBL-harboring bacteria. We discuss the case of a 39-year-old patient who presented with tibial osteomyelitis growing MBL-producing Citrobacter sedlakii. He was successfully treated with ceftazidime-avibactam and aztreonam combination therapy. We discuss the importance of developing new antibiotic regimens for the growing threat of MDR organisms with special consideration of MBL.
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spelling pubmed-95368432022-10-11 A Case of New Delhi Metallo-β-Lactamases (NDM) Citrobacter sedlakii Osteomyelitis Successfully Treated With Ceftazidime-Avibactam and Aztreonam Rubnitz, Zachary A Kunkel, Victoria N Baselski, Vickie S Summers, Nathan A Cureus Infectious Disease There have been an increase in multi-drug resistant (MDR) organisms causing infections with high mortality and morbidity. Bacteria that carry metallo-β-lactamases (MBLs) are particularly dangerous. Novel antibiotic combinations, such as ceftazidime-avibactam with aztreonam, are in clinical trials for the treatment of MBL-harboring bacteria. We discuss the case of a 39-year-old patient who presented with tibial osteomyelitis growing MBL-producing Citrobacter sedlakii. He was successfully treated with ceftazidime-avibactam and aztreonam combination therapy. We discuss the importance of developing new antibiotic regimens for the growing threat of MDR organisms with special consideration of MBL. Cureus 2022-09-06 /pmc/articles/PMC9536843/ /pubmed/36225496 http://dx.doi.org/10.7759/cureus.28855 Text en Copyright © 2022, Rubnitz et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Infectious Disease
Rubnitz, Zachary A
Kunkel, Victoria N
Baselski, Vickie S
Summers, Nathan A
A Case of New Delhi Metallo-β-Lactamases (NDM) Citrobacter sedlakii Osteomyelitis Successfully Treated With Ceftazidime-Avibactam and Aztreonam
title A Case of New Delhi Metallo-β-Lactamases (NDM) Citrobacter sedlakii Osteomyelitis Successfully Treated With Ceftazidime-Avibactam and Aztreonam
title_full A Case of New Delhi Metallo-β-Lactamases (NDM) Citrobacter sedlakii Osteomyelitis Successfully Treated With Ceftazidime-Avibactam and Aztreonam
title_fullStr A Case of New Delhi Metallo-β-Lactamases (NDM) Citrobacter sedlakii Osteomyelitis Successfully Treated With Ceftazidime-Avibactam and Aztreonam
title_full_unstemmed A Case of New Delhi Metallo-β-Lactamases (NDM) Citrobacter sedlakii Osteomyelitis Successfully Treated With Ceftazidime-Avibactam and Aztreonam
title_short A Case of New Delhi Metallo-β-Lactamases (NDM) Citrobacter sedlakii Osteomyelitis Successfully Treated With Ceftazidime-Avibactam and Aztreonam
title_sort case of new delhi metallo-β-lactamases (ndm) citrobacter sedlakii osteomyelitis successfully treated with ceftazidime-avibactam and aztreonam
topic Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536843/
https://www.ncbi.nlm.nih.gov/pubmed/36225496
http://dx.doi.org/10.7759/cureus.28855
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