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Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity

Various mechanisms have been suggested to explain the chemopreventive and tumor-inhibitory effects of melatonin. Despite the growing evidence supporting melatonin-induced mitochondrial dysfunction, it remains largely unknown how this phenomenon modulates metabolic reprogramming in cancer cells. The...

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Detalles Bibliográficos
Autores principales: Lee, Seunghyeong, Byun, Jun-Kyu, Kim, Na-Young, Jin, Jonghwa, Woo, Hyein, Choi, Yeon-Kyung, Park, Keun-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537022/
https://www.ncbi.nlm.nih.gov/pubmed/35651333
http://dx.doi.org/10.5483/BMBRep.2022.55.9.177