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The functional connectivity of language network across the life span: Disentangling the effects of typical aging from Alzheimer’s disease

Language is usually characterized as the most preserved cognitive function during typical aging. Several neuroimaging studies have shown that healthy aging is characterized by inter-network compensation which correlates with better language performance. On the contrary, language deficits occur early...

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Autores principales: Rafiq, Marie, Jucla, Mélanie, Guerrier, Laura, Péran, Patrice, Pariente, Jérémie, Pistono, Aurélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537133/
https://www.ncbi.nlm.nih.gov/pubmed/36212038
http://dx.doi.org/10.3389/fnagi.2022.959405
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author Rafiq, Marie
Jucla, Mélanie
Guerrier, Laura
Péran, Patrice
Pariente, Jérémie
Pistono, Aurélie
author_facet Rafiq, Marie
Jucla, Mélanie
Guerrier, Laura
Péran, Patrice
Pariente, Jérémie
Pistono, Aurélie
author_sort Rafiq, Marie
collection PubMed
description Language is usually characterized as the most preserved cognitive function during typical aging. Several neuroimaging studies have shown that healthy aging is characterized by inter-network compensation which correlates with better language performance. On the contrary, language deficits occur early in the course of Alzheimer’s disease (AD). Therefore, this study compares young participants, healthy older participants, and prodromal AD participants, to characterize functional connectivity changes in language due to healthy aging or prodromal AD. We first compared measures of integrated local correlations (ILCs) and fractional amplitude of low-frequency oscillations (fALFFs) in language areas. We showed that both groups of older adults had lower connectivity values within frontal language-related areas. In the healthy older group, higher integrated local correlation (ILC) and fALFF values in frontal areas were positively correlated with fluency and naming tasks. We then performed seed-based analyses for more precise discrimination between healthy aging and prodromal AD. Healthy older adults showed no functional alterations at a seed-based level when the seed area was not or only slightly impaired compared to the young adults [i.e., inferior frontal gyrus (IFG)], while prodromal AD participants also showed decreased connectivity at a seed-based level. On the contrary, when the seed area was similarly impaired in healthy older adults and prodromal AD participants on ILC and fALFF measures, their connectivity maps were also similar during seed-to-voxel analyses [i.e., superior frontal gyrus (SFG)]. Current results show that functional connectivity measures at a voxel level (ILC and fALFF) are already impacted in healthy aging. These findings imply that the functional compensations observed in healthy aging depend on the functional integrity of brain areas at a voxel level.
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spelling pubmed-95371332022-10-08 The functional connectivity of language network across the life span: Disentangling the effects of typical aging from Alzheimer’s disease Rafiq, Marie Jucla, Mélanie Guerrier, Laura Péran, Patrice Pariente, Jérémie Pistono, Aurélie Front Aging Neurosci Neuroscience Language is usually characterized as the most preserved cognitive function during typical aging. Several neuroimaging studies have shown that healthy aging is characterized by inter-network compensation which correlates with better language performance. On the contrary, language deficits occur early in the course of Alzheimer’s disease (AD). Therefore, this study compares young participants, healthy older participants, and prodromal AD participants, to characterize functional connectivity changes in language due to healthy aging or prodromal AD. We first compared measures of integrated local correlations (ILCs) and fractional amplitude of low-frequency oscillations (fALFFs) in language areas. We showed that both groups of older adults had lower connectivity values within frontal language-related areas. In the healthy older group, higher integrated local correlation (ILC) and fALFF values in frontal areas were positively correlated with fluency and naming tasks. We then performed seed-based analyses for more precise discrimination between healthy aging and prodromal AD. Healthy older adults showed no functional alterations at a seed-based level when the seed area was not or only slightly impaired compared to the young adults [i.e., inferior frontal gyrus (IFG)], while prodromal AD participants also showed decreased connectivity at a seed-based level. On the contrary, when the seed area was similarly impaired in healthy older adults and prodromal AD participants on ILC and fALFF measures, their connectivity maps were also similar during seed-to-voxel analyses [i.e., superior frontal gyrus (SFG)]. Current results show that functional connectivity measures at a voxel level (ILC and fALFF) are already impacted in healthy aging. These findings imply that the functional compensations observed in healthy aging depend on the functional integrity of brain areas at a voxel level. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9537133/ /pubmed/36212038 http://dx.doi.org/10.3389/fnagi.2022.959405 Text en Copyright © 2022 Rafiq, Jucla, Guerrier, Péran, Pariente and Pistono. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Rafiq, Marie
Jucla, Mélanie
Guerrier, Laura
Péran, Patrice
Pariente, Jérémie
Pistono, Aurélie
The functional connectivity of language network across the life span: Disentangling the effects of typical aging from Alzheimer’s disease
title The functional connectivity of language network across the life span: Disentangling the effects of typical aging from Alzheimer’s disease
title_full The functional connectivity of language network across the life span: Disentangling the effects of typical aging from Alzheimer’s disease
title_fullStr The functional connectivity of language network across the life span: Disentangling the effects of typical aging from Alzheimer’s disease
title_full_unstemmed The functional connectivity of language network across the life span: Disentangling the effects of typical aging from Alzheimer’s disease
title_short The functional connectivity of language network across the life span: Disentangling the effects of typical aging from Alzheimer’s disease
title_sort functional connectivity of language network across the life span: disentangling the effects of typical aging from alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537133/
https://www.ncbi.nlm.nih.gov/pubmed/36212038
http://dx.doi.org/10.3389/fnagi.2022.959405
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