Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity

Protein disulfide isomerase (PDI) is an endoplasmic reticulum (ER) enzyme that mediates the formation of disulfide bonds, and is also a therapeutic target for cancer treatment. Our previous studies found that PDI mediates apoptotic signaling by inducing mitochondrial dysfunction. Considering that mi...

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Detalles Bibliográficos
Autores principales: Wang, Ruru, Shang, Yajing, Chen, Bin, Xu, Feng, Zhang, Jie, Zhang, Zhaoyang, Zhao, Xipeng, Wan, Xiangbo, Xu, An, Wu, Lijun, Zhao, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537141/
https://www.ncbi.nlm.nih.gov/pubmed/36202782
http://dx.doi.org/10.1038/s41419-022-05302-w

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