The Role of miRNA in Ovarian Cancer: an Overview

Ovarian cancer (OC) is a highly malignant disease that seriously threatens women’s health and poses challenges for clinicians. MicroRNAs (miRNAs) have recently been intensively studied in the field of oncology due to their regulatory roles in gene expressions through RNA degradation and/or translati...

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Autores principales: Zhao, Lihui, Liang, Xiaolei, Wang, Liyan, Zhang, Xuehong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537199/
https://www.ncbi.nlm.nih.gov/pubmed/34973152
http://dx.doi.org/10.1007/s43032-021-00717-w
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author Zhao, Lihui
Liang, Xiaolei
Wang, Liyan
Zhang, Xuehong
author_facet Zhao, Lihui
Liang, Xiaolei
Wang, Liyan
Zhang, Xuehong
author_sort Zhao, Lihui
collection PubMed
description Ovarian cancer (OC) is a highly malignant disease that seriously threatens women’s health and poses challenges for clinicians. MicroRNAs (miRNAs) have recently been intensively studied in the field of oncology due to their regulatory roles in gene expressions through RNA degradation and/or translation inhibition. This review summarizes the current studies on miRNAs in OC and introduces the latest updates of miRNAs in the early screening, treatment, and prognostic prediction of OC, thereby demonstrating the clinical significance of miRNAs in OC. Further exploration on potential targets of miRNAs in OC may provide new insights on optimizing the diagnosis and treatment of OC. MiRNAs are important driving factors for the progression of OC and the dysregulation of miRNAs can serve as biomarkers in the diagnosis, treatment and prognosis of OC. Therefore, miRNAs are potential biological targets for early screening, targeted therapy, drug resistance monitoring, and prognosis improvement in malignancies such as OC.
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spelling pubmed-95371992022-10-08 The Role of miRNA in Ovarian Cancer: an Overview Zhao, Lihui Liang, Xiaolei Wang, Liyan Zhang, Xuehong Reprod Sci Review Ovarian cancer (OC) is a highly malignant disease that seriously threatens women’s health and poses challenges for clinicians. MicroRNAs (miRNAs) have recently been intensively studied in the field of oncology due to their regulatory roles in gene expressions through RNA degradation and/or translation inhibition. This review summarizes the current studies on miRNAs in OC and introduces the latest updates of miRNAs in the early screening, treatment, and prognostic prediction of OC, thereby demonstrating the clinical significance of miRNAs in OC. Further exploration on potential targets of miRNAs in OC may provide new insights on optimizing the diagnosis and treatment of OC. MiRNAs are important driving factors for the progression of OC and the dysregulation of miRNAs can serve as biomarkers in the diagnosis, treatment and prognosis of OC. Therefore, miRNAs are potential biological targets for early screening, targeted therapy, drug resistance monitoring, and prognosis improvement in malignancies such as OC. Springer International Publishing 2022-01-01 /pmc/articles/PMC9537199/ /pubmed/34973152 http://dx.doi.org/10.1007/s43032-021-00717-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Zhao, Lihui
Liang, Xiaolei
Wang, Liyan
Zhang, Xuehong
The Role of miRNA in Ovarian Cancer: an Overview
title The Role of miRNA in Ovarian Cancer: an Overview
title_full The Role of miRNA in Ovarian Cancer: an Overview
title_fullStr The Role of miRNA in Ovarian Cancer: an Overview
title_full_unstemmed The Role of miRNA in Ovarian Cancer: an Overview
title_short The Role of miRNA in Ovarian Cancer: an Overview
title_sort role of mirna in ovarian cancer: an overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537199/
https://www.ncbi.nlm.nih.gov/pubmed/34973152
http://dx.doi.org/10.1007/s43032-021-00717-w
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