The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation

Dead End (DND1) is an RNA-binding protein essential for germline development through its role in post-transcriptional gene regulation. The molecular mechanisms behind selection and regulation of its targets are unknown. Here, we present the solution structure of DND1’s tandem RNA Recognition Motifs...

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Detalles Bibliográficos
Autores principales: Duszczyk, Malgorzata M., Wischnewski, Harry, Kazeeva, Tamara, Arora, Rajika, Loughlin, Fionna E., von Schroetter, Christine, Pradère, Ugo, Hall, Jonathan, Ciaudo, Constance, Allain, Frédéric H.-T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537309/
https://www.ncbi.nlm.nih.gov/pubmed/36202814
http://dx.doi.org/10.1038/s41467-022-33552-x

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