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Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology

Mutations in the GBA gene that encodes the lysosomal enzyme β-glucocerebrosidase (GCase) are a major genetic risk factor for Parkinson’s disease (PD). In this study, we generated a set of differentiated and stable human dopaminergic cell lines that express the two most prevalent GBA mutations as wel...

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Detalles Bibliográficos
Autores principales:	Navarro-Romero, Alba, Fernandez-Gonzalez, Irene, Riera, Jordi, Montpeyo, Marta, Albert-Bayo, Merce, Lopez-Royo, Tresa, Castillo-Sanchez, Pablo, Carnicer-Caceres, Clara, Arranz-Amo, Jose Antonio, Castillo-Ribelles, Laura, Pradas, Eddie, Casas, Josefina, Vila, Miquel, Martinez-Vicente, Marta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537323/ https://www.ncbi.nlm.nih.gov/pubmed/36202848 http://dx.doi.org/10.1038/s41531-022-00397-6

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