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Histamine and histamine receptors: Roles in major depressive disorder
Although the incidence of major depressive disorder (MDD) is high and its social impact is great, we still know very little about the pathophysiology of depression. The monoamine hypothesis of depression suggests that 5-HT, NE, and DA synergistically affect mood, which is the basis of current drug t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537353/ https://www.ncbi.nlm.nih.gov/pubmed/36213905 http://dx.doi.org/10.3389/fpsyt.2022.825591 |
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author | Qian, Hong Shu, Chang Xiao, Ling Wang, Gaohua |
author_facet | Qian, Hong Shu, Chang Xiao, Ling Wang, Gaohua |
author_sort | Qian, Hong |
collection | PubMed |
description | Although the incidence of major depressive disorder (MDD) is high and its social impact is great, we still know very little about the pathophysiology of depression. The monoamine hypothesis of depression suggests that 5-HT, NE, and DA synergistically affect mood, which is the basis of current drug therapy for depression. However, histamine as a monoamine transmitter is rarely studied. Our review is the first time to illustrate the effect of histaminergic system on depression in order to find the way for the development of new antidepressant drugs. The brain neurotransmitter histamine is involved in MDD, and the brain histaminergic system operates through four receptors. Histamine and its receptors can also regulate the immune response to improve symptoms of depression. In addition, H3R can interact with other depression-related transmitters (including 5-HT, DA, GLU, and MCH); thus, histamine may participate in the occurrence of depression through other neural circuits. Notably, in rodent studies, several H3R and H1R antagonists were found to be safe and effective in alleviating depression-like behavior. To highlight the complex functions of histamine in depression, and reveals that histamine receptors can be used as new targets for antidepressant therapy. |
format | Online Article Text |
id | pubmed-9537353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95373532022-10-08 Histamine and histamine receptors: Roles in major depressive disorder Qian, Hong Shu, Chang Xiao, Ling Wang, Gaohua Front Psychiatry Psychiatry Although the incidence of major depressive disorder (MDD) is high and its social impact is great, we still know very little about the pathophysiology of depression. The monoamine hypothesis of depression suggests that 5-HT, NE, and DA synergistically affect mood, which is the basis of current drug therapy for depression. However, histamine as a monoamine transmitter is rarely studied. Our review is the first time to illustrate the effect of histaminergic system on depression in order to find the way for the development of new antidepressant drugs. The brain neurotransmitter histamine is involved in MDD, and the brain histaminergic system operates through four receptors. Histamine and its receptors can also regulate the immune response to improve symptoms of depression. In addition, H3R can interact with other depression-related transmitters (including 5-HT, DA, GLU, and MCH); thus, histamine may participate in the occurrence of depression through other neural circuits. Notably, in rodent studies, several H3R and H1R antagonists were found to be safe and effective in alleviating depression-like behavior. To highlight the complex functions of histamine in depression, and reveals that histamine receptors can be used as new targets for antidepressant therapy. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9537353/ /pubmed/36213905 http://dx.doi.org/10.3389/fpsyt.2022.825591 Text en Copyright © 2022 Qian, Shu, Xiao and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Qian, Hong Shu, Chang Xiao, Ling Wang, Gaohua Histamine and histamine receptors: Roles in major depressive disorder |
title | Histamine and histamine receptors: Roles in major depressive disorder |
title_full | Histamine and histamine receptors: Roles in major depressive disorder |
title_fullStr | Histamine and histamine receptors: Roles in major depressive disorder |
title_full_unstemmed | Histamine and histamine receptors: Roles in major depressive disorder |
title_short | Histamine and histamine receptors: Roles in major depressive disorder |
title_sort | histamine and histamine receptors: roles in major depressive disorder |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537353/ https://www.ncbi.nlm.nih.gov/pubmed/36213905 http://dx.doi.org/10.3389/fpsyt.2022.825591 |
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