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Histamine and histamine receptors: Roles in major depressive disorder

Although the incidence of major depressive disorder (MDD) is high and its social impact is great, we still know very little about the pathophysiology of depression. The monoamine hypothesis of depression suggests that 5-HT, NE, and DA synergistically affect mood, which is the basis of current drug t...

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Autores principales: Qian, Hong, Shu, Chang, Xiao, Ling, Wang, Gaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537353/
https://www.ncbi.nlm.nih.gov/pubmed/36213905
http://dx.doi.org/10.3389/fpsyt.2022.825591
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author Qian, Hong
Shu, Chang
Xiao, Ling
Wang, Gaohua
author_facet Qian, Hong
Shu, Chang
Xiao, Ling
Wang, Gaohua
author_sort Qian, Hong
collection PubMed
description Although the incidence of major depressive disorder (MDD) is high and its social impact is great, we still know very little about the pathophysiology of depression. The monoamine hypothesis of depression suggests that 5-HT, NE, and DA synergistically affect mood, which is the basis of current drug therapy for depression. However, histamine as a monoamine transmitter is rarely studied. Our review is the first time to illustrate the effect of histaminergic system on depression in order to find the way for the development of new antidepressant drugs. The brain neurotransmitter histamine is involved in MDD, and the brain histaminergic system operates through four receptors. Histamine and its receptors can also regulate the immune response to improve symptoms of depression. In addition, H3R can interact with other depression-related transmitters (including 5-HT, DA, GLU, and MCH); thus, histamine may participate in the occurrence of depression through other neural circuits. Notably, in rodent studies, several H3R and H1R antagonists were found to be safe and effective in alleviating depression-like behavior. To highlight the complex functions of histamine in depression, and reveals that histamine receptors can be used as new targets for antidepressant therapy.
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spelling pubmed-95373532022-10-08 Histamine and histamine receptors: Roles in major depressive disorder Qian, Hong Shu, Chang Xiao, Ling Wang, Gaohua Front Psychiatry Psychiatry Although the incidence of major depressive disorder (MDD) is high and its social impact is great, we still know very little about the pathophysiology of depression. The monoamine hypothesis of depression suggests that 5-HT, NE, and DA synergistically affect mood, which is the basis of current drug therapy for depression. However, histamine as a monoamine transmitter is rarely studied. Our review is the first time to illustrate the effect of histaminergic system on depression in order to find the way for the development of new antidepressant drugs. The brain neurotransmitter histamine is involved in MDD, and the brain histaminergic system operates through four receptors. Histamine and its receptors can also regulate the immune response to improve symptoms of depression. In addition, H3R can interact with other depression-related transmitters (including 5-HT, DA, GLU, and MCH); thus, histamine may participate in the occurrence of depression through other neural circuits. Notably, in rodent studies, several H3R and H1R antagonists were found to be safe and effective in alleviating depression-like behavior. To highlight the complex functions of histamine in depression, and reveals that histamine receptors can be used as new targets for antidepressant therapy. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9537353/ /pubmed/36213905 http://dx.doi.org/10.3389/fpsyt.2022.825591 Text en Copyright © 2022 Qian, Shu, Xiao and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Qian, Hong
Shu, Chang
Xiao, Ling
Wang, Gaohua
Histamine and histamine receptors: Roles in major depressive disorder
title Histamine and histamine receptors: Roles in major depressive disorder
title_full Histamine and histamine receptors: Roles in major depressive disorder
title_fullStr Histamine and histamine receptors: Roles in major depressive disorder
title_full_unstemmed Histamine and histamine receptors: Roles in major depressive disorder
title_short Histamine and histamine receptors: Roles in major depressive disorder
title_sort histamine and histamine receptors: roles in major depressive disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537353/
https://www.ncbi.nlm.nih.gov/pubmed/36213905
http://dx.doi.org/10.3389/fpsyt.2022.825591
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