Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAF(V600E) inhibition resistance in melanoma

Targeted cancer therapies have revolutionized treatment but their efficacies are limited by the development of resistance driven by clonal evolution within tumors. We developed “CAPTURE”, a single-cell barcoding approach to comprehensively trace clonal dynamics and capture live lineage-coupled resis...

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Detalles Bibliográficos
Autores principales: Zhang, Ze-Yan, Ding, Yingwen, Ezhilarasan, Ravesanker, Lhakhang, Tenzin, Wang, Qianghu, Yang, Jie, Modrek, Aram S., Zhang, Hua, Tsirigos, Aristotelis, Futreal, Andrew, Draetta, Giulio F., Verhaak, Roel G. W., Sulman, Erik P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537441/
https://www.ncbi.nlm.nih.gov/pubmed/36202798
http://dx.doi.org/10.1038/s41421-022-00462-7

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