TPMT and NUDT15 testing for thiopurine therapy: A major tertiary hospital experience and lessons learned

Variants in thiopurine methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) are associated with an accumulation of cytotoxic metabolites leading to increased risk of drug-related toxicity with standard doses of thiopurine drugs. We established TPMT and NUDT15 genetic testing for clinical use and...

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Detalles Bibliográficos
Autores principales: Goh, Liuh Ling, Lim, Chia Wei, Leong, Khai Pang, Ong, Kiat Hoe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537458/
https://www.ncbi.nlm.nih.gov/pubmed/36210828
http://dx.doi.org/10.3389/fphar.2022.837164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537458/
https://www.ncbi.nlm.nih.gov/pubmed/36210828
http://dx.doi.org/10.3389/fphar.2022.837164

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