Diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation

Cytomegalovirus (CMV) infection remains a frequent complication after hematopoietic stem cell transplantation (HSCT) and causes significant morbidity and mortality in transplantation recipients. In this review, we highlight the role of major risk factors that are associated with the incidence of CMV...

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Autores principales: Cui, Jiaqi, Zhao, Kui, Sun, Yanling, Wen, Ruijuan, Zhang, Xiangzhong, Li, Xudong, Long, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537469/
https://www.ncbi.nlm.nih.gov/pubmed/36211358
http://dx.doi.org/10.3389/fimmu.2022.971156
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author Cui, Jiaqi
Zhao, Kui
Sun, Yanling
Wen, Ruijuan
Zhang, Xiangzhong
Li, Xudong
Long, Bing
author_facet Cui, Jiaqi
Zhao, Kui
Sun, Yanling
Wen, Ruijuan
Zhang, Xiangzhong
Li, Xudong
Long, Bing
author_sort Cui, Jiaqi
collection PubMed
description Cytomegalovirus (CMV) infection remains a frequent complication after hematopoietic stem cell transplantation (HSCT) and causes significant morbidity and mortality in transplantation recipients. In this review, we highlight the role of major risk factors that are associated with the incidence of CMV infection. Advances in immunosurveillance may predict CMV infection, allowing early interventions to prevent severe infection. Furthermore, numerous therapeutic strategies against CMV infection after HSCT are summarized. A comprehensive understanding of the current situation of CMV treatment may provide a hint for clinical practice and even promote the development of novel strategies for precision medicine.
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spelling pubmed-95374692022-10-08 Diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation Cui, Jiaqi Zhao, Kui Sun, Yanling Wen, Ruijuan Zhang, Xiangzhong Li, Xudong Long, Bing Front Immunol Immunology Cytomegalovirus (CMV) infection remains a frequent complication after hematopoietic stem cell transplantation (HSCT) and causes significant morbidity and mortality in transplantation recipients. In this review, we highlight the role of major risk factors that are associated with the incidence of CMV infection. Advances in immunosurveillance may predict CMV infection, allowing early interventions to prevent severe infection. Furthermore, numerous therapeutic strategies against CMV infection after HSCT are summarized. A comprehensive understanding of the current situation of CMV treatment may provide a hint for clinical practice and even promote the development of novel strategies for precision medicine. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9537469/ /pubmed/36211358 http://dx.doi.org/10.3389/fimmu.2022.971156 Text en Copyright © 2022 Cui, Zhao, Sun, Wen, Zhang, Li and Long https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cui, Jiaqi
Zhao, Kui
Sun, Yanling
Wen, Ruijuan
Zhang, Xiangzhong
Li, Xudong
Long, Bing
Diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation
title Diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation
title_full Diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation
title_fullStr Diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation
title_full_unstemmed Diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation
title_short Diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation
title_sort diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537469/
https://www.ncbi.nlm.nih.gov/pubmed/36211358
http://dx.doi.org/10.3389/fimmu.2022.971156
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