Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression?

Immunotherapy has shown great promise in treating various types of malignant tumors. However, some patients with gastrointestinal cancer have been known to experience rapid disease progression after treatment, a situation referred to as hyperprogressive disease (HPD). This minireview focuses on the...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Mo-Xuan, Gao, Shu-Yue, Yang, Fan, Fan, Run-Jia, Yang, Qin-Na, Zhang, Tian-Lan, Qian, Nian-Song, Dai, Guang-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537503/
https://www.ncbi.nlm.nih.gov/pubmed/36212599
http://dx.doi.org/10.5306/wjco.v13.i9.729
_version_ 1784803215697510400
author Wang, Mo-Xuan
Gao, Shu-Yue
Yang, Fan
Fan, Run-Jia
Yang, Qin-Na
Zhang, Tian-Lan
Qian, Nian-Song
Dai, Guang-Hai
author_facet Wang, Mo-Xuan
Gao, Shu-Yue
Yang, Fan
Fan, Run-Jia
Yang, Qin-Na
Zhang, Tian-Lan
Qian, Nian-Song
Dai, Guang-Hai
author_sort Wang, Mo-Xuan
collection PubMed
description Immunotherapy has shown great promise in treating various types of malignant tumors. However, some patients with gastrointestinal cancer have been known to experience rapid disease progression after treatment, a situation referred to as hyperprogressive disease (HPD). This minireview focuses on the definitions and potential mechanisms of HPD, natural disease progression in gastrointestinal malignancies, and tumor immunological microenvironment.
format Online
Article
Text
id pubmed-9537503
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-95375032022-10-08 Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression? Wang, Mo-Xuan Gao, Shu-Yue Yang, Fan Fan, Run-Jia Yang, Qin-Na Zhang, Tian-Lan Qian, Nian-Song Dai, Guang-Hai World J Clin Oncol Minireviews Immunotherapy has shown great promise in treating various types of malignant tumors. However, some patients with gastrointestinal cancer have been known to experience rapid disease progression after treatment, a situation referred to as hyperprogressive disease (HPD). This minireview focuses on the definitions and potential mechanisms of HPD, natural disease progression in gastrointestinal malignancies, and tumor immunological microenvironment. Baishideng Publishing Group Inc 2022-09-24 2022-09-24 /pmc/articles/PMC9537503/ /pubmed/36212599 http://dx.doi.org/10.5306/wjco.v13.i9.729 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Wang, Mo-Xuan
Gao, Shu-Yue
Yang, Fan
Fan, Run-Jia
Yang, Qin-Na
Zhang, Tian-Lan
Qian, Nian-Song
Dai, Guang-Hai
Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression?
title Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression?
title_full Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression?
title_fullStr Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression?
title_full_unstemmed Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression?
title_short Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression?
title_sort hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: a natural process of advanced tumor progression?
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537503/
https://www.ncbi.nlm.nih.gov/pubmed/36212599
http://dx.doi.org/10.5306/wjco.v13.i9.729
work_keys_str_mv AT wangmoxuan hyperprogressionundertreatmentwithimmunecheckpointinhibitorsinpatientswithgastrointestinalcanceranaturalprocessofadvancedtumorprogression
AT gaoshuyue hyperprogressionundertreatmentwithimmunecheckpointinhibitorsinpatientswithgastrointestinalcanceranaturalprocessofadvancedtumorprogression
AT yangfan hyperprogressionundertreatmentwithimmunecheckpointinhibitorsinpatientswithgastrointestinalcanceranaturalprocessofadvancedtumorprogression
AT fanrunjia hyperprogressionundertreatmentwithimmunecheckpointinhibitorsinpatientswithgastrointestinalcanceranaturalprocessofadvancedtumorprogression
AT yangqinna hyperprogressionundertreatmentwithimmunecheckpointinhibitorsinpatientswithgastrointestinalcanceranaturalprocessofadvancedtumorprogression
AT zhangtianlan hyperprogressionundertreatmentwithimmunecheckpointinhibitorsinpatientswithgastrointestinalcanceranaturalprocessofadvancedtumorprogression
AT qianniansong hyperprogressionundertreatmentwithimmunecheckpointinhibitorsinpatientswithgastrointestinalcanceranaturalprocessofadvancedtumorprogression
AT daiguanghai hyperprogressionundertreatmentwithimmunecheckpointinhibitorsinpatientswithgastrointestinalcanceranaturalprocessofadvancedtumorprogression

Ejemplares similares