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Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation

Transvertebral magnetic stimulation (TVMS) of the human lumbar spinal cord can evoke bilateral rhythmic leg movements, as in walking, supposedly through the activation of spinal locomotor neural circuitry. However, an appropriate stimulus intensity that can effectively drive the human spinal locomot...

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Autores principales: Kawai, Kazutake, Tazoe, Toshiki, Yanai, Toshimasa, Kanosue, Kazuyuki, Nishimura, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537552/
https://www.ncbi.nlm.nih.gov/pubmed/36211130
http://dx.doi.org/10.3389/fnhum.2022.1016064
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author Kawai, Kazutake
Tazoe, Toshiki
Yanai, Toshimasa
Kanosue, Kazuyuki
Nishimura, Yukio
author_facet Kawai, Kazutake
Tazoe, Toshiki
Yanai, Toshimasa
Kanosue, Kazuyuki
Nishimura, Yukio
author_sort Kawai, Kazutake
collection PubMed
description Transvertebral magnetic stimulation (TVMS) of the human lumbar spinal cord can evoke bilateral rhythmic leg movements, as in walking, supposedly through the activation of spinal locomotor neural circuitry. However, an appropriate stimulus intensity that can effectively drive the human spinal locomotor circuitry to evoke walking-like movements has not been determined. To address this issue, TVMS was delivered over an intervertebral space of the lumbar cord (L1–L3) at different stimulus intensities (10–70% of maximum stimulator output) in healthy human adults. In a stimulus intensity-dependent manner, TVMS evoked two major patterns of rhythmic leg movements in which the left-right movement cycles were coordinated with different phase relationships: hopping-like movements, in which both legs moved in the same direction in phase, and walking-like movements, in which both legs moved alternatively in anti-phase; uncategorized movements were also observed which could not be categorized as either movement type. Even at the same stimulation site, the stimulus-evoked rhythmic movements changed from hopping-like movements to walking-like movements as stimulus intensity was increased. Different leg muscle activation patterns were engaged in the induction of the hopping- and walking-like movements. The magnitude of the evoked hopping- and walking-like movements was positively correlated with stimulus intensity. The human spinal neural circuitry required a higher intensity of magnetic stimulation to produce walking-like leg movements than to produce hopping-like movements. These results suggest that TVMS activates distinct neural modules in the human spinal cord to generate hopping- and walking-like movements.
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spelling pubmed-95375522022-10-08 Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation Kawai, Kazutake Tazoe, Toshiki Yanai, Toshimasa Kanosue, Kazuyuki Nishimura, Yukio Front Hum Neurosci Neuroscience Transvertebral magnetic stimulation (TVMS) of the human lumbar spinal cord can evoke bilateral rhythmic leg movements, as in walking, supposedly through the activation of spinal locomotor neural circuitry. However, an appropriate stimulus intensity that can effectively drive the human spinal locomotor circuitry to evoke walking-like movements has not been determined. To address this issue, TVMS was delivered over an intervertebral space of the lumbar cord (L1–L3) at different stimulus intensities (10–70% of maximum stimulator output) in healthy human adults. In a stimulus intensity-dependent manner, TVMS evoked two major patterns of rhythmic leg movements in which the left-right movement cycles were coordinated with different phase relationships: hopping-like movements, in which both legs moved in the same direction in phase, and walking-like movements, in which both legs moved alternatively in anti-phase; uncategorized movements were also observed which could not be categorized as either movement type. Even at the same stimulation site, the stimulus-evoked rhythmic movements changed from hopping-like movements to walking-like movements as stimulus intensity was increased. Different leg muscle activation patterns were engaged in the induction of the hopping- and walking-like movements. The magnitude of the evoked hopping- and walking-like movements was positively correlated with stimulus intensity. The human spinal neural circuitry required a higher intensity of magnetic stimulation to produce walking-like leg movements than to produce hopping-like movements. These results suggest that TVMS activates distinct neural modules in the human spinal cord to generate hopping- and walking-like movements. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9537552/ /pubmed/36211130 http://dx.doi.org/10.3389/fnhum.2022.1016064 Text en Copyright © 2022 Kawai, Tazoe, Yanai, Kanosue and Nishimura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kawai, Kazutake
Tazoe, Toshiki
Yanai, Toshimasa
Kanosue, Kazuyuki
Nishimura, Yukio
Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation
title Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation
title_full Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation
title_fullStr Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation
title_full_unstemmed Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation
title_short Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation
title_sort activation of human spinal locomotor circuitry using transvertebral magnetic stimulation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537552/
https://www.ncbi.nlm.nih.gov/pubmed/36211130
http://dx.doi.org/10.3389/fnhum.2022.1016064
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