Cargando…

Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions

Vitamin D is considered to be the main mediator of the beneficial effects of sun exposure. In humans, highest expression of Vitamin D receptors is found in the intestinal tract. In addition, 1α,25-dihydroxyvitamin D3 (or calcitriol), the most active Vitamin D metabolite, plays important homeostatic...

Descripción completa

Detalles Bibliográficos
Autores principales: Na, Soo-Young, Kim, Ki Bae, Lim, Yun Jeong, Song, Hyun Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Cancer Prevention 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537583/
https://www.ncbi.nlm.nih.gov/pubmed/36258716
http://dx.doi.org/10.15430/JCP.2022.27.3.147
_version_ 1784803235612065792
author Na, Soo-Young
Kim, Ki Bae
Lim, Yun Jeong
Song, Hyun Joo
author_facet Na, Soo-Young
Kim, Ki Bae
Lim, Yun Jeong
Song, Hyun Joo
author_sort Na, Soo-Young
collection PubMed
description Vitamin D is considered to be the main mediator of the beneficial effects of sun exposure. In humans, highest expression of Vitamin D receptors is found in the intestinal tract. In addition, 1α,25-dihydroxyvitamin D3 (or calcitriol), the most active Vitamin D metabolite, plays important homeostatic roles in the intestine, particularly calcium absorption. Vitamin D deficiency is defined as a serum 25-hydroxyvitamin D [25(OH)D] level of < 20 ng/mL. Previous studies show that higher circulating 25(OH)D levels are associated with reduced risk of colorectal cancer (CRC) and improved survival. Most research to date has been conducted in animals, specifically mice. Although human studies have a limited number of participants, one study recruiting a large cohort of patients with advanced or metastatic CRC revealed that higher plasma 25(OH)D levels are associated with improved overall and progression-free survival. However, the effects of Vitamin D supplementation on incidence and mortality of CRC remain inconclusive. Although Vitamin D may help to prevent cancer, there is a paucity of research demonstrating conclusively that Vitamin D alters prognosis after chemotherapy. Here, we review the mechanisms by which Vitamin D affects CRC, as well as the results of clinical, epidemiological, and human intervention studies. We also discuss current perspectives and future directions regarding Vitamin D and CRC.
format Online
Article
Text
id pubmed-9537583
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Korean Society of Cancer Prevention
record_format MEDLINE/PubMed
spelling pubmed-95375832022-10-17 Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions Na, Soo-Young Kim, Ki Bae Lim, Yun Jeong Song, Hyun Joo J Cancer Prev Review Vitamin D is considered to be the main mediator of the beneficial effects of sun exposure. In humans, highest expression of Vitamin D receptors is found in the intestinal tract. In addition, 1α,25-dihydroxyvitamin D3 (or calcitriol), the most active Vitamin D metabolite, plays important homeostatic roles in the intestine, particularly calcium absorption. Vitamin D deficiency is defined as a serum 25-hydroxyvitamin D [25(OH)D] level of < 20 ng/mL. Previous studies show that higher circulating 25(OH)D levels are associated with reduced risk of colorectal cancer (CRC) and improved survival. Most research to date has been conducted in animals, specifically mice. Although human studies have a limited number of participants, one study recruiting a large cohort of patients with advanced or metastatic CRC revealed that higher plasma 25(OH)D levels are associated with improved overall and progression-free survival. However, the effects of Vitamin D supplementation on incidence and mortality of CRC remain inconclusive. Although Vitamin D may help to prevent cancer, there is a paucity of research demonstrating conclusively that Vitamin D alters prognosis after chemotherapy. Here, we review the mechanisms by which Vitamin D affects CRC, as well as the results of clinical, epidemiological, and human intervention studies. We also discuss current perspectives and future directions regarding Vitamin D and CRC. Korean Society of Cancer Prevention 2022-09-30 2022-09-30 /pmc/articles/PMC9537583/ /pubmed/36258716 http://dx.doi.org/10.15430/JCP.2022.27.3.147 Text en Copyright © 2022 Korean Society of Cancer Prevention https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Na, Soo-Young
Kim, Ki Bae
Lim, Yun Jeong
Song, Hyun Joo
Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions
title Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions
title_full Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions
title_fullStr Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions
title_full_unstemmed Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions
title_short Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions
title_sort vitamin d and colorectal cancer: current perspectives and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537583/
https://www.ncbi.nlm.nih.gov/pubmed/36258716
http://dx.doi.org/10.15430/JCP.2022.27.3.147
work_keys_str_mv AT nasooyoung vitamindandcolorectalcancercurrentperspectivesandfuturedirections
AT kimkibae vitamindandcolorectalcancercurrentperspectivesandfuturedirections
AT limyunjeong vitamindandcolorectalcancercurrentperspectivesandfuturedirections
AT songhyunjoo vitamindandcolorectalcancercurrentperspectivesandfuturedirections