Use of Immune Checkpoint Inhibitors in Elderly Patients With Chronic Kidney Disease and Renal Cell Carcinoma Metastasis of the Parotid Gland: Case Report and Review of the Literature

Renal cell carcinoma metastasis of the parotid gland is extremely rare, and the present literature review found only 23 cases reported in the last two decades. We present a case of a 75-year-old woman with a colon cancer history who had parotid gland metastasis as the first manifestation of second p...

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Autores principales: Parosanu, Andreea, Orlov Slavu, Cristina, Pirlog, Cristina, Stanciu, Ioana M, Nitipir, Cornelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
General Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537597/
https://www.ncbi.nlm.nih.gov/pubmed/36225438
http://dx.doi.org/10.7759/cureus.28868
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author Parosanu, Andreea
Orlov Slavu, Cristina
Pirlog, Cristina
Stanciu, Ioana M
Nitipir, Cornelia
author_facet Parosanu, Andreea
Orlov Slavu, Cristina
Pirlog, Cristina
Stanciu, Ioana M
Nitipir, Cornelia
author_sort Parosanu, Andreea
collection PubMed
description Renal cell carcinoma metastasis of the parotid gland is extremely rare, and the present literature review found only 23 cases reported in the last two decades. We present a case of a 75-year-old woman with a colon cancer history who had parotid gland metastasis as the first manifestation of second primary kidney cancer. The presence of multiple comorbidities affected medical decision-making. Therefore the patient was treated primarily with immunotherapy. After four cycles of dual immune checkpoint blockade, this advanced patient still benefited and was changed to nivolumab monotherapy as maintenance therapy.
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spelling pubmed-95375972022-10-11 Use of Immune Checkpoint Inhibitors in Elderly Patients With Chronic Kidney Disease and Renal Cell Carcinoma Metastasis of the Parotid Gland: Case Report and Review of the Literature Parosanu, Andreea Orlov Slavu, Cristina Pirlog, Cristina Stanciu, Ioana M Nitipir, Cornelia Cureus General Surgery Renal cell carcinoma metastasis of the parotid gland is extremely rare, and the present literature review found only 23 cases reported in the last two decades. We present a case of a 75-year-old woman with a colon cancer history who had parotid gland metastasis as the first manifestation of second primary kidney cancer. The presence of multiple comorbidities affected medical decision-making. Therefore the patient was treated primarily with immunotherapy. After four cycles of dual immune checkpoint blockade, this advanced patient still benefited and was changed to nivolumab monotherapy as maintenance therapy. Cureus 2022-09-06 /pmc/articles/PMC9537597/ /pubmed/36225438 http://dx.doi.org/10.7759/cureus.28868 Text en Copyright © 2022, Parosanu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle General Surgery
Parosanu, Andreea
Orlov Slavu, Cristina
Pirlog, Cristina
Stanciu, Ioana M
Nitipir, Cornelia
Use of Immune Checkpoint Inhibitors in Elderly Patients With Chronic Kidney Disease and Renal Cell Carcinoma Metastasis of the Parotid Gland: Case Report and Review of the Literature
title Use of Immune Checkpoint Inhibitors in Elderly Patients With Chronic Kidney Disease and Renal Cell Carcinoma Metastasis of the Parotid Gland: Case Report and Review of the Literature
title_full Use of Immune Checkpoint Inhibitors in Elderly Patients With Chronic Kidney Disease and Renal Cell Carcinoma Metastasis of the Parotid Gland: Case Report and Review of the Literature
title_fullStr Use of Immune Checkpoint Inhibitors in Elderly Patients With Chronic Kidney Disease and Renal Cell Carcinoma Metastasis of the Parotid Gland: Case Report and Review of the Literature
title_full_unstemmed Use of Immune Checkpoint Inhibitors in Elderly Patients With Chronic Kidney Disease and Renal Cell Carcinoma Metastasis of the Parotid Gland: Case Report and Review of the Literature
title_short Use of Immune Checkpoint Inhibitors in Elderly Patients With Chronic Kidney Disease and Renal Cell Carcinoma Metastasis of the Parotid Gland: Case Report and Review of the Literature
title_sort use of immune checkpoint inhibitors in elderly patients with chronic kidney disease and renal cell carcinoma metastasis of the parotid gland: case report and review of the literature
topic General Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537597/
https://www.ncbi.nlm.nih.gov/pubmed/36225438
http://dx.doi.org/10.7759/cureus.28868
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