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Cardiovascular manifestations identified by multi-modality imaging in patients with long COVID

BACKGROUND: The possibility of permanent cardiovascular damage causing cardiovascular long COVID has been suggested; however, data are insufficient. This study investigated the prevalence of cardiovascular disorders, particularly in patients with cardiovascular long COVID using multi-modality imagin...

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Autores principales: Murata, Nobuhiro, Yamada, Akimasa, Fujito, Hidesato, Hashimoto, Naoki, Nagao, Tetsuro, Tanaka, Yudai, Fukumoto, Katsunori, Arai, Riku, Wakamatsu, Yuji, Ebuchi, Yasunari, Monden, Masaki, Kojima, Keisuke, Hayashi, Kentaro, Gon, Yasuhiro, Okumura, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537639/
https://www.ncbi.nlm.nih.gov/pubmed/36211553
http://dx.doi.org/10.3389/fcvm.2022.968584
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author Murata, Nobuhiro
Yamada, Akimasa
Fujito, Hidesato
Hashimoto, Naoki
Nagao, Tetsuro
Tanaka, Yudai
Fukumoto, Katsunori
Arai, Riku
Wakamatsu, Yuji
Ebuchi, Yasunari
Monden, Masaki
Kojima, Keisuke
Hayashi, Kentaro
Gon, Yasuhiro
Okumura, Yasuo
author_facet Murata, Nobuhiro
Yamada, Akimasa
Fujito, Hidesato
Hashimoto, Naoki
Nagao, Tetsuro
Tanaka, Yudai
Fukumoto, Katsunori
Arai, Riku
Wakamatsu, Yuji
Ebuchi, Yasunari
Monden, Masaki
Kojima, Keisuke
Hayashi, Kentaro
Gon, Yasuhiro
Okumura, Yasuo
author_sort Murata, Nobuhiro
collection PubMed
description BACKGROUND: The possibility of permanent cardiovascular damage causing cardiovascular long COVID has been suggested; however, data are insufficient. This study investigated the prevalence of cardiovascular disorders, particularly in patients with cardiovascular long COVID using multi-modality imaging. METHODS: A total of 584 patients admitted to the hospital due to COVID-19 between January 2020 and September 2021 were initially considered. Upon outpatient follow-up, 52 (9%) were suspected to have cardiovascular long COVID, had complaints of chest pain, dyspnea, or palpitations, and were finally enrolled in this study. This study is registered with the Japanese University Hospital Medical Information Network (UMIN 000047978). RESULTS: Of 52 patients with long COVID who were followed up in the outpatient clinic for cardiovascular symptoms, cardiovascular disorders were present in 27% (14/52). Among them, 15% (8/52) had myocardial injury, 8% (4/52) pulmonary embolisms, and 4% (2/52) both. The incidence of a severe condition (36% [5/14] vs. 8% [3/38], p = 0.014) and in-hospital cardiac events (71% [10/14] vs. 24% [9/38], p = 0.002) was significantly higher in patients with cardiovascular disorders than in those without. A multivariate logistic regression analysis revealed that a severe condition (OR, 5.789; 95% CI 1.442–45.220; p = 0.017) and in-hospital cardiac events (OR, 8.079; 95% CI 1.306–25.657; p = 0.021) were independent risk factors of cardiovascular disorders in cardiovascular long COVID patients. CONCLUSIONS: Suspicion of cardiovascular involvement in patients with cardiovascular long COVID in this study was approximately 30%. A severe condition during hospitalization and in-hospital cardiac events were risk factors of a cardiovascular sequalae in CV long COVID patients.
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spelling pubmed-95376392022-10-08 Cardiovascular manifestations identified by multi-modality imaging in patients with long COVID Murata, Nobuhiro Yamada, Akimasa Fujito, Hidesato Hashimoto, Naoki Nagao, Tetsuro Tanaka, Yudai Fukumoto, Katsunori Arai, Riku Wakamatsu, Yuji Ebuchi, Yasunari Monden, Masaki Kojima, Keisuke Hayashi, Kentaro Gon, Yasuhiro Okumura, Yasuo Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: The possibility of permanent cardiovascular damage causing cardiovascular long COVID has been suggested; however, data are insufficient. This study investigated the prevalence of cardiovascular disorders, particularly in patients with cardiovascular long COVID using multi-modality imaging. METHODS: A total of 584 patients admitted to the hospital due to COVID-19 between January 2020 and September 2021 were initially considered. Upon outpatient follow-up, 52 (9%) were suspected to have cardiovascular long COVID, had complaints of chest pain, dyspnea, or palpitations, and were finally enrolled in this study. This study is registered with the Japanese University Hospital Medical Information Network (UMIN 000047978). RESULTS: Of 52 patients with long COVID who were followed up in the outpatient clinic for cardiovascular symptoms, cardiovascular disorders were present in 27% (14/52). Among them, 15% (8/52) had myocardial injury, 8% (4/52) pulmonary embolisms, and 4% (2/52) both. The incidence of a severe condition (36% [5/14] vs. 8% [3/38], p = 0.014) and in-hospital cardiac events (71% [10/14] vs. 24% [9/38], p = 0.002) was significantly higher in patients with cardiovascular disorders than in those without. A multivariate logistic regression analysis revealed that a severe condition (OR, 5.789; 95% CI 1.442–45.220; p = 0.017) and in-hospital cardiac events (OR, 8.079; 95% CI 1.306–25.657; p = 0.021) were independent risk factors of cardiovascular disorders in cardiovascular long COVID patients. CONCLUSIONS: Suspicion of cardiovascular involvement in patients with cardiovascular long COVID in this study was approximately 30%. A severe condition during hospitalization and in-hospital cardiac events were risk factors of a cardiovascular sequalae in CV long COVID patients. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9537639/ /pubmed/36211553 http://dx.doi.org/10.3389/fcvm.2022.968584 Text en Copyright © 2022 Murata, Yamada, Fujito, Hashimoto, Nagao, Tanaka, Fukumoto, Arai, Wakamatsu, Ebuchi, Monden, Kojima, Hayashi, Gon and Okumura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Murata, Nobuhiro
Yamada, Akimasa
Fujito, Hidesato
Hashimoto, Naoki
Nagao, Tetsuro
Tanaka, Yudai
Fukumoto, Katsunori
Arai, Riku
Wakamatsu, Yuji
Ebuchi, Yasunari
Monden, Masaki
Kojima, Keisuke
Hayashi, Kentaro
Gon, Yasuhiro
Okumura, Yasuo
Cardiovascular manifestations identified by multi-modality imaging in patients with long COVID
title Cardiovascular manifestations identified by multi-modality imaging in patients with long COVID
title_full Cardiovascular manifestations identified by multi-modality imaging in patients with long COVID
title_fullStr Cardiovascular manifestations identified by multi-modality imaging in patients with long COVID
title_full_unstemmed Cardiovascular manifestations identified by multi-modality imaging in patients with long COVID
title_short Cardiovascular manifestations identified by multi-modality imaging in patients with long COVID
title_sort cardiovascular manifestations identified by multi-modality imaging in patients with long covid
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537639/
https://www.ncbi.nlm.nih.gov/pubmed/36211553
http://dx.doi.org/10.3389/fcvm.2022.968584
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