Mechanisms of FLASH effect

FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can reduce radiation-induced damage in healthy tissue,...

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Detalles Bibliográficos
Autores principales: Lin, Binwei, Huang, Dan, Gao, Feng, Yang, Yiwei, Wu, Dai, Zhang, Yu, Feng, Gang, Dai, Tangzhi, Du, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537695/
https://www.ncbi.nlm.nih.gov/pubmed/36212435
http://dx.doi.org/10.3389/fonc.2022.995612
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author Lin, Binwei
Huang, Dan
Gao, Feng
Yang, Yiwei
Wu, Dai
Zhang, Yu
Feng, Gang
Dai, Tangzhi
Du, Xiaobo
author_facet Lin, Binwei
Huang, Dan
Gao, Feng
Yang, Yiwei
Wu, Dai
Zhang, Yu
Feng, Gang
Dai, Tangzhi
Du, Xiaobo
author_sort Lin, Binwei
collection PubMed
description FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can reduce radiation-induced damage in healthy tissue, and second, FLASH-RT can retain antitumor effectiveness. Current research shows that mechanisms of the biological effects of FLASH-RT are related to oxygen. However, due to the short time of FLASH-RT, evidences related to the mechanisms are indirect, and the exact mechanisms of the biological effects of FLASH-RT are not completely clear and some are even contradictory. This review focuses on the mechanisms of the biological effects of FLASH-RT and proposes future research directions.
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spelling pubmed-95376952022-10-08 Mechanisms of FLASH effect Lin, Binwei Huang, Dan Gao, Feng Yang, Yiwei Wu, Dai Zhang, Yu Feng, Gang Dai, Tangzhi Du, Xiaobo Front Oncol Oncology FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can reduce radiation-induced damage in healthy tissue, and second, FLASH-RT can retain antitumor effectiveness. Current research shows that mechanisms of the biological effects of FLASH-RT are related to oxygen. However, due to the short time of FLASH-RT, evidences related to the mechanisms are indirect, and the exact mechanisms of the biological effects of FLASH-RT are not completely clear and some are even contradictory. This review focuses on the mechanisms of the biological effects of FLASH-RT and proposes future research directions. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9537695/ /pubmed/36212435 http://dx.doi.org/10.3389/fonc.2022.995612 Text en Copyright © 2022 Lin, Huang, Gao, Yang, Wu, Zhang, Feng, Dai and Du https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lin, Binwei
Huang, Dan
Gao, Feng
Yang, Yiwei
Wu, Dai
Zhang, Yu
Feng, Gang
Dai, Tangzhi
Du, Xiaobo
Mechanisms of FLASH effect
title Mechanisms of FLASH effect
title_full Mechanisms of FLASH effect
title_fullStr Mechanisms of FLASH effect
title_full_unstemmed Mechanisms of FLASH effect
title_short Mechanisms of FLASH effect
title_sort mechanisms of flash effect
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537695/
https://www.ncbi.nlm.nih.gov/pubmed/36212435
http://dx.doi.org/10.3389/fonc.2022.995612
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